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Olfactory performance and resting state functional connectivity in non-demented drug naïve patients with Parkinson's disease

DC Field Value Language
dc.contributor.author함지현-
dc.contributor.author홍진용-
dc.contributor.author손영호-
dc.contributor.author이필휴-
dc.date.accessioned2016-02-04T11:13:16Z-
dc.date.available2016-02-04T11:13:16Z-
dc.date.issued2015-
dc.identifier.issn1065-9471-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139935-
dc.description.abstractOlfactory performance in Parkinson's disease (PD) is closely associated with subsequent cognitive decline. In the present study, we analyzed the olfaction-dependent functional connectivity with a hypothesis that olfactory performance would influence functional connectivity within key brain areas of PD. A total of 110 nondemented drug-naïve patients with PD were subdivided into three groups of high score (PD-H, n = 23), middle score (PD-M, n = 64), and low score (PD-L, n = 23) based on olfactory performance. We performed the resting-state functional connectivity with seed region of interest in the posterior cingulate cortex (PCC) and caudate. An analysis of functional connectivity revealed that PD-L patients exhibited a significant attenuation of cortical functional connectivity with the PCC in the bilateral primary sensory areas, right frontal areas, and right parietal areas compared to PD-H or PD-M patients. Meanwhile, PD-L patients exhibited a significant enhancement of striatocortical functional connectivity in the bilateral occipital areas and right frontal areas compared to PD-H or PD-M patients. In the voxel-wise correlation analysis, olfactory performance was positively associated with cortical functional connectivity with the PCC in similar areas of attenuated cortical connectivity in PD-L patients relative to PD-H patients. On the other hand, the cortical functional connectivity with the caudate was negatively correlated with olfactory performance in similar areas of increased connectivity in PD-L patients relative to PD-H patients. The present study demonstrated that resting state functional connectivity exhibits a distinctive pattern depending on olfactory performance, which might shed light on a meaningful relationship between olfactory impairment and cognitive dysfunction in PD.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1716~1727-
dc.relation.isPartOfHUMAN BRAIN MAPPING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHBrain/pathology-
dc.subject.MESHBrain/physiopathology*-
dc.subject.MESHBrain Mapping-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeural Pathways/pathology-
dc.subject.MESHNeural Pathways/physiopathology-
dc.subject.MESHNeuropsychological Tests-
dc.subject.MESHOlfactory Perception/physiology*-
dc.subject.MESHParkinson Disease/pathology-
dc.subject.MESHParkinson Disease/physiopathology*-
dc.subject.MESHRest-
dc.titleOlfactory performance and resting state functional connectivity in non-demented drug naïve patients with Parkinson's disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학)-
dc.contributor.googleauthorMun Kyung Sunwoo-
dc.contributor.googleauthorJungho Cha-
dc.contributor.googleauthorJee Hyun Ham-
dc.contributor.googleauthorSook K. Song-
dc.contributor.googleauthorJin Yong Hong-
dc.contributor.googleauthorJong-Min Lee-
dc.contributor.googleauthorYoung H. Sohn-
dc.contributor.googleauthorPhil Hyu Lee-
dc.identifier.doi10.1002/hbm.22732-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04338-
dc.contributor.localIdA04442-
dc.contributor.localIdA01982-
dc.contributor.localIdA03270-
dc.relation.journalcodeJ01004-
dc.identifier.eissn1097-0193-
dc.identifier.pmid25640661-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/hbm.22732/abstract-
dc.subject.keywordParkinson's disease-
dc.subject.keywordcognition-
dc.subject.keywordolfaction-
dc.subject.keywordresting state functional connectivity-
dc.contributor.alternativeNameHam, Jee Hyun-
dc.contributor.alternativeNameHong, Jin Yong-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.alternativeNameLee, Phil Hyu-
dc.contributor.affiliatedAuthorHam, Jee Hyun-
dc.contributor.affiliatedAuthorHong, Jin Yong-
dc.contributor.affiliatedAuthorSohn, Young Ho-
dc.contributor.affiliatedAuthorLee, Phil Hyu-
dc.rights.accessRightsnot free-
dc.citation.volume36-
dc.citation.number5-
dc.citation.startPage1716-
dc.citation.endPage1727-
dc.identifier.bibliographicCitationHUMAN BRAIN MAPPING, Vol.36(5) : 1716-1727, 2015-
dc.identifier.rimsid48389-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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