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The Evaluation of Osseointegration of Dental Implant Surface with Different Size of TiO2 Nanotube in Rats

Authors
 Young Ah Yi  ;  Young Bum Park  ;  Hyunmin Choi  ;  Keun Woo Lee  ;  Sun Jai Kim  ;  Kwang Mahn Kim  ;  Seunghan Oh  ;  June Sung Shim 
Citation
 Journal of Nanomaterials, Vol.2015 : 1-11, 2015 
Journal Title
 Journal of Nanomaterials 
ISSN
 1687-4110 
Issue Date
2015
Abstract
With the development of nanotechnology, many researches have shown that nanometer-scaled materials especially TiO2 nanotube have a positive effect on cellular behavior and surface characteristics of implant, which are considered to be crucial factors in osseointegration. However, it has not yet been verified which nanotube size is effective in osseointegration in vivo. The aim of this study was to evaluate the effect of implant surface-treated with different size of TiO2 nanotubes on osseointegration in rat femur. The customized implants (threaded and nonthreaded type), surface-treated with different diameter of TiO2 nanotubes (30 nm, 50 nm, 70 nm, and 100 nm nanotube), were placed on both sides of the femur of 50 male Sprague-Dawley rats (6 weeks old). Rats were sacrificed at 2 and 6 weeks following surgery; then the specimens were collected by perfusion fixation and the osseointegration of implants was evaluated by radiographic and histologic analyses and removal torque value test. The mean of bone area (%) and the mean of removal torque were different in each group, indicating that the difference in TiO2 nanotube size may influence new bone formation and osseointegration in rats.
Full Text
http://www.hindawi.com/journals/jnm/2015/581713/abs/
DOI
10.1155/2015/581713
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실) > 1. Journal Papers
Yonsei Authors
Park, Young Bum(박영범)
Shim, June Sung(심준성) ORCID logo https://orcid.org/0000-0003-1428-0122
Lee, Keun Woo(이근우) ORCID logo https://orcid.org/0000-0002-3153-190X
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139923
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