180 216

Cited 11 times in

Prognostic effect of matrix metalloproteinase-9 in patients with resected Non small cell lung cancer

 Chang Young Lee  ;  Hyo Sup Shim  ;  Seokkee Lee  ;  Jin Gu Lee  ;  Dae Joon Kim  ;  Kyung Young Chung 
 Journal of Cardiothoracic Surgery, Vol.10 : 44, 2015 
Journal Title
 Journal of Cardiothoracic Surgery 
Issue Date
Adenocarcinoma/diagnosis ; Adenocarcinoma/metabolism ; Adenocarcinoma/mortality ; Adenocarcinoma/surgery* ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/metabolism* ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/surgery* ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/mortality ; Carcinoma, Squamous Cell/surgery* ; Female ; Follow-Up Studies ; Humans ; Immunohistochemistry ; Lung Neoplasms/diagnosis ; Lung Neoplasms/metabolism ; Lung Neoplasms/mortality ; Lung Neoplasms/surgery* ; Male ; Matrix Metalloproteinase 9/metabolism* ; Middle Aged ; Neoplasm Recurrence, Local ; Pneumonectomy*/mortality ; Prognosis ; Retrospective Studies ; Survival Analysis
Matrix metalloproteinase-9 (MMP-9) ; Immunohistochemistry ; Non-small cell lung cancer (NSCLC) ; Lung adenocarcinoma ; Prognostic factor
BACKGROUND: The role of tumor matrix metalloproteinase-9 (MMP-9) expression in non-small cell lung cancer (NSCLC) remains controversial. In this study, we investigated the prognostic value of tumor MMP-9 expression and other clinicopathologic factors in patients with completely resected NSCLC. METHODS: This retrospective study included patients who underwent complete resection of pathological stage I-IIIA NSCLC at Severance Hospital, Seoul, Korea, between 1998 and 2009. Tumor samples of 417 patients were stained by immunohistochemistry, and the expression of MMP-9 in tumor cells was evaluated, using the median immunohistochemical score of 10 (range, 0-300) as the cut-off. RESULTS: Tumor MMP-9 expression was observed in 161 (38.6%) of 417 patients. Log-rank analysis showed a significant association of tumor MMP-9 expression with shortened disease-free survival (p = 0.01) but not with overall survival (p = 0.109). Multivariate analysis demonstrated that tumor MMP-9 expression was not an independent prognostic factor of recurrence (p = 0.142) or survival (p = 0.807). However, among patients with adenocarcinoma, tumor MMP-9 expression was associated with relapse (p = 0.003) and poor survival (p = 0.033). Furthermore, tumor MMP-9 expression was an independent prognostic indicator of relapse in patients with adenocarcinoma (p = 0.035). CONCLUSIONS: Among patients with NSCLC, tumor MMP-9 expression was associated with poor outcomes in those with adenocarcinoma, but not in those with squamous cell carcinoma. In addition, MMP-9 expression was identified as an independent predictor of relapse of completely resected lung adenocarcinoma.
Files in This Item:
T201501076.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dae Joon(김대준)
Shim, Hyo Sup(심효섭) ORCID logo https://orcid.org/0000-0002-5718-3624
Lee, Jin Gu(이진구)
Lee, Chang Young(이창영)
Chung, Kyung Young(정경영)
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.