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Neointimal response to second-generation drug-eluting stents in diabetic patients with de-novo coronary lesions: intravascular ultrasound study

Authors
 Won, Hoyoun  ;  Kang, Tae Soo  ;  Hong, Bum-Kee  ;  Lee, Seunghwan  ;  Jeon, Dong Woon  ;  Ryu, Sung Kee  ;  Min, Pil-Ki  ;  Yoon, Young Won  ;  Lee, Byoung Kwon  ;  Kwon, Hyuck Moon  ;  Ko, Young-Guk  ;  Jang, Yangsoo 
Citation
 Coronary Artery Disease, Vol.26(3) : 212-219, 2015 
Journal Title
 Coronary Artery Disease 
ISSN
 0954-6928 
Issue Date
2015
Abstract
OBJECTIVES: The aim of this study was to evaluate the extent of neointimal response after the implantation of a second-generation drug-eluting stent, zotarolimus-eluting stent (ZES-ER, Endeavor Resolute) or everolimus-eluting stent (EES, Xience V), using intravascular ultrasound (IVUS) in diabetic patients. MATERIALS AND METHODS: In all, 154 diabetic patients with de-novo coronary lesions were randomized to be implanted with a ZES-ER or EES, and the angiographic follow-up at 9 months combined with a complete IVUS study was available for 96 patients with 101 lesions. RESULTS: Baseline demographic and lesion parameters were similar in both groups at index percutaneous coronary intervention. On follow-up angiography, in-stent late lumen loss and minimal lumen diameter were not different between the two groups. On IVUS study, neointimal hyperplasia volume [median (interquartile range): ZES-ER vs. EES; 2.25 mm (0.57-6.25) vs. 1.59 mm (0.45-8.37), P=0.615] and in-stent percentage of volume obstruction [median (interquartile range): ZES-ER vs. EES; 1.16% (0.33-3.61) vs. 0.77% (0.29-4.01), P=0.615] showed similar results between the two groups. CONCLUSION: In diabetic patients, the second-generation drug-eluting stents, ZES-ER and EES, were comparable in inhibiting neointimal proliferation.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00019501-201505000-00005&LSLINK=80&D=ovft
DOI
10.1097/MCA.0000000000000195
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
고영국(Ko, Young Guk) ORCID logo https://orcid.org/0000-0001-7748-5788
권혁문(Kwon, Hyuck Moon) ORCID logo https://orcid.org/0000-0001-9901-5015
민필기(Min, Pil Ki) ORCID logo https://orcid.org/0000-0001-7033-7651
원호연(Won, Ho Youn)
윤영원(Yoon, Young Won) ORCID logo https://orcid.org/0000-0002-0907-0350
이병권(Lee, Byoung Kwon) ORCID logo https://orcid.org/0000-0001-9259-2776
장양수(Jang, Yang Soo) ORCID logo https://orcid.org/0000-0002-2169-3112
홍범기(Hong, Bum Kee) ORCID logo https://orcid.org/0000-0002-6456-0184
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139911
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