Cited 15 times in
Analysis of the roles of glucose transporter 1 and hexokinase 2 in the metabolism of glucose by extrahepatic bile duct cancer cells
DC Field | Value | Language |
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dc.contributor.author | 김재근 | - |
dc.contributor.author | 박준성 | - |
dc.contributor.author | 유영훈 | - |
dc.contributor.author | 유정식 | - |
dc.contributor.author | 윤동섭 | - |
dc.contributor.author | 윤선옥 | - |
dc.contributor.author | 이재훈 | - |
dc.contributor.author | 전태주 | - |
dc.date.accessioned | 2016-02-04T11:10:43Z | - |
dc.date.available | 2016-02-04T11:10:43Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0363-9762 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139841 | - |
dc.description.abstract | PURPOSE OF THE REPORT: Extrahepatic bile duct (EHD) cancer varies in uptake of FDG. The aim of the present study was to determine the role of glucose transporter (GLUT) 1 and hexokinase (HK) 2 in the glucose metabolism of EHD cancer cells using immunohistochemistry and 18F-FDG PET/CT. METHODS: Twenty-six patients with EHD cancer who underwent baseline PET/CT and surgery were studied. Biopsies were immunohistochemically analyzed using antibodies against GLUT1 and HK2, and the expression was scored from 0 to 4 according to the percentage of stained cells. SUV and tumor-to-liver ratio (T/L ratio) were obtained from 18F-FDG PET/CT data. SUV and T/L ratio and GLUT1 and HK2 expression were compared with histological grades and tumor locations (proximal and distal EHD) to correlate glucose metabolism with the expression of GLUT1 and HK2. RESULTS: SUV, T/L ratio, and GLUT1 and HK2 expression did not differ as a function of histological grade and tumor location. GLUT1 and HK2 were expressed in 20 (76.9%) and 22 (84.6%) of 26 tumor biopsies, respectively. The GLUT1 score, SUV, and T/L ratio increased, and the GLUT1 score, but not the HK2 score, correlated significantly with SUV (ρ = 0.648) and T/L ratio (ρ = 0.703). There was no direct correlation between the expression of GLUT1 and that of HK2 (ρ = 0.2046, P = 0.3161). CONCLUSIONS: Although GLUT1 and HK2 regulate intracellular accumulation of FDG in many cancers, only GLUT1 expression was correlated with FDG uptake by EHD cancers. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | e178~e182 | - |
dc.relation.isPartOf | CLINICAL NUCLEAR MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/diagnostic imaging* | - |
dc.subject.MESH | Adenocarcinoma/metabolism | - |
dc.subject.MESH | Adenocarcinoma/pathology | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Bile Duct Neoplasms/diagnostic imaging* | - |
dc.subject.MESH | Bile Duct Neoplasms/metabolism | - |
dc.subject.MESH | Bile Duct Neoplasms/pathology | - |
dc.subject.MESH | Bile Ducts, Extrahepatic/diagnostic imaging | - |
dc.subject.MESH | Bile Ducts, Extrahepatic/metabolism | - |
dc.subject.MESH | Bile Ducts, Extrahepatic/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fluorodeoxyglucose F18 | - |
dc.subject.MESH | Glucose/metabolism* | - |
dc.subject.MESH | Glucose Transporter Type 1/genetics | - |
dc.subject.MESH | Glucose Transporter Type 1/metabolism* | - |
dc.subject.MESH | Hexokinase/genetics | - |
dc.subject.MESH | Hexokinase/metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multimodal Imaging | - |
dc.subject.MESH | Positron-Emission Tomography | - |
dc.subject.MESH | Radiopharmaceuticals | - |
dc.subject.MESH | Tomography, X-Ray Computed | - |
dc.title | Analysis of the roles of glucose transporter 1 and hexokinase 2 in the metabolism of glucose by extrahepatic bile duct cancer cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Yoon, Sun Och | - |
dc.contributor.googleauthor | Jeon, Tae Joo | - |
dc.contributor.googleauthor | Park, Joon Seong | - |
dc.contributor.googleauthor | Ryu, Yong Hoon | - |
dc.contributor.googleauthor | Lee, Jae-Hoon | - |
dc.contributor.googleauthor | Yoo, Jung Sik | - |
dc.contributor.googleauthor | Kim, Jae Keun | - |
dc.contributor.googleauthor | Yoon, Dong Sup | - |
dc.contributor.googleauthor | Oh, Eun Ji | - |
dc.identifier.doi | 10.1097/RLU.0000000000000640 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00857 | - |
dc.contributor.localId | A01672 | - |
dc.contributor.localId | A02485 | - |
dc.contributor.localId | A02500 | - |
dc.contributor.localId | A02548 | - |
dc.contributor.localId | A02566 | - |
dc.contributor.localId | A03557 | - |
dc.contributor.localId | A03093 | - |
dc.relation.journalcode | J00595 | - |
dc.identifier.eissn | 1536-0229 | - |
dc.identifier.pmid | 25608150 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00003072-201503000-00032&LSLINK=80&D=ovft | - |
dc.subject.keyword | 18F-FDG | - |
dc.subject.keyword | cholangiocarcinoma | - |
dc.subject.keyword | glucose transporter | - |
dc.subject.keyword | hexokinase | - |
dc.contributor.alternativeName | Kim, Jae Keun | - |
dc.contributor.alternativeName | Park, Joon Seong | - |
dc.contributor.alternativeName | Ryu, Young Hoon | - |
dc.contributor.alternativeName | Yu, Jeong Sik | - |
dc.contributor.alternativeName | Yoon, Dong Sup | - |
dc.contributor.alternativeName | Yoon, Sun Och | - |
dc.contributor.alternativeName | Lee, Jae Hoon | - |
dc.contributor.alternativeName | Jeon, Tae Joo | - |
dc.contributor.affiliatedAuthor | Kim, Jae Keun | - |
dc.contributor.affiliatedAuthor | Park, Joon Seong | - |
dc.contributor.affiliatedAuthor | Ryu, Young Hoon | - |
dc.contributor.affiliatedAuthor | Yu, Jeong Sik | - |
dc.contributor.affiliatedAuthor | Yoon, Dong Sup | - |
dc.contributor.affiliatedAuthor | Yoon, Sun Och | - |
dc.contributor.affiliatedAuthor | Jeon, Tae Joo | - |
dc.contributor.affiliatedAuthor | Lee, Jae Hoon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 40 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 178 | - |
dc.citation.endPage | 182 | - |
dc.identifier.bibliographicCitation | CLINICAL NUCLEAR MEDICINE, Vol.40(3) : 178-182, 2015 | - |
dc.identifier.rimsid | 46591 | - |
dc.type.rims | ART | - |
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