Cited 28 times in
Fibroblast growth factor receptor 1 gene amplification is associated with poor survival in patients with resected esophageal squamous cell carcinoma.
DC Field | Value | Language |
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dc.contributor.author | 김혜련 | - |
dc.contributor.author | 김효송 | - |
dc.contributor.author | 박준철 | - |
dc.contributor.author | 신성관 | - |
dc.contributor.author | 이상길 | - |
dc.contributor.author | 이용찬 | - |
dc.contributor.author | 이창걸 | - |
dc.contributor.author | 정다현 | - |
dc.contributor.author | 정현수 | - |
dc.contributor.author | 조병철 | - |
dc.contributor.author | 허진 | - |
dc.contributor.author | 김대준 | - |
dc.contributor.author | 김주항 | - |
dc.contributor.author | 김현기 | - |
dc.date.accessioned | 2016-02-04T11:10:09Z | - |
dc.date.available | 2016-02-04T11:10:09Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139820 | - |
dc.description.abstract | To investigate the frequency and the prognostic impact of fibroblast growth factor receptor 1 (FGFR1) gene amplification in 526 curatively resected esophageal squamous cell carcinoma (ESCC). Using fluorescent in situ hybridization, high amplification was defined by an FGFR1/centromer 8 ratio is ≥ 2.0, or average number of FGFR1 signals/tumor cell nucleus ≥ 6.0, or percentage of tumor cells containing ≥ 15 FGFR1 signals or large cluster in ≥ 10%. Low amplification was defined by ≥ 5 FGFR1 signals in ≥ 50%. FGFR2 and FGFR3 mutations were assessed by direct sequencing in 388 cases and no mutation was detected. High and low amplification were detected in 8.6% and 1.1%, respectively. High FGFR1 amplification had significantly shorter disease-free survival (34.0 vs 158.5 months P=0.019) and overall survival (52.2 vs not reached P=0.022) than low/no amplification group. After adjusting for sex, smoking, stage, histology, and adjuvant treatment, high FGFR1 amplification had a greater risk of recurrence (adjusted hazard ratio [AHR], 1.6; P=0.029) and death (AHR, 1.53; P=0.050). High amplification was significantly higher in current smokers than former and never-smokers (Ptrend<0.001) and increased proportional to smoking dosage. High FGFR1 amplification is a frequent oncogenic alteration and an independent poor prognostic factor in resected ESCC. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 2562~2572 | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Carcinoma, Squamous Cell/genetics* | - |
dc.subject.MESH | Carcinoma, Squamous Cell/pathology | - |
dc.subject.MESH | Carcinoma, Squamous Cell/therapy | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Esophageal Neoplasms/genetics* | - |
dc.subject.MESH | Esophageal Neoplasms/pathology | - |
dc.subject.MESH | Esophageal Neoplasms/therapy | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Amplification* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | In Situ Hybridization, Fluorescence | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Recurrence, Local | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Receptor, Fibroblast Growth Factor, Type 1/genetics* | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Smoking | - |
dc.title | Fibroblast growth factor receptor 1 gene amplification is associated with poor survival in patients with resected esophageal squamous cell carcinoma. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Hyo Song Kim | - |
dc.contributor.googleauthor | Seung Eun Lee | - |
dc.contributor.googleauthor | Yoon Sung Bae | - |
dc.contributor.googleauthor | Dae Joon Kim | - |
dc.contributor.googleauthor | Chang‑Geol Lee | - |
dc.contributor.googleauthor | Jin Hur | - |
dc.contributor.googleauthor | Hyunsoo Chung | - |
dc.contributor.googleauthor | Jun Chul Park | - |
dc.contributor.googleauthor | Da Hyun Jung | - |
dc.contributor.googleauthor | Sung Kwan Shin | - |
dc.contributor.googleauthor | Sang Kil Lee | - |
dc.contributor.googleauthor | Yong Chan Lee | - |
dc.contributor.googleauthor | Hye Ryun Kim | - |
dc.contributor.googleauthor | Yong Wha Moon | - |
dc.contributor.googleauthor | Joo Hang Kim | - |
dc.contributor.googleauthor | Young Mog Shim | - |
dc.contributor.googleauthor | Susan S. Jewell | - |
dc.contributor.googleauthor | Hyunki Kim | - |
dc.contributor.googleauthor | Yoon-La Choi | - |
dc.contributor.googleauthor | Byoung Chul Cho | - |
dc.identifier.doi | 10.18632/oncotarget.2944 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01166 | - |
dc.contributor.localId | A01202 | - |
dc.contributor.localId | A01676 | - |
dc.contributor.localId | A02112 | - |
dc.contributor.localId | A02812 | - |
dc.contributor.localId | A02988 | - |
dc.contributor.localId | A03240 | - |
dc.contributor.localId | A03591 | - |
dc.contributor.localId | A03822 | - |
dc.contributor.localId | A04370 | - |
dc.contributor.localId | A00368 | - |
dc.contributor.localId | A00945 | - |
dc.contributor.localId | A01108 | - |
dc.relation.journalcode | J02421 | - |
dc.identifier.eissn | 1949-2553 | - |
dc.identifier.pmid | 25537505 | - |
dc.subject.keyword | Fibroblast growth factor receptor 1 | - |
dc.subject.keyword | esophageal squamous cell carcinoma | - |
dc.subject.keyword | gene amplification | - |
dc.subject.keyword | fluorescent in situ hybridization | - |
dc.subject.keyword | prognostic factor | - |
dc.contributor.alternativeName | Kim, Hye Ryun | - |
dc.contributor.alternativeName | Kim, Hyo Song | - |
dc.contributor.alternativeName | Park, Jun Chul | - |
dc.contributor.alternativeName | Shin, Sung Kwan | - |
dc.contributor.alternativeName | Lee, Sang Kil | - |
dc.contributor.alternativeName | Lee, Yong Chan | - |
dc.contributor.alternativeName | Lee, Chang Geol | - |
dc.contributor.alternativeName | Jung, Da Hyun | - |
dc.contributor.alternativeName | Chung, Hyun Soo | - |
dc.contributor.alternativeName | Cho, Byoung Chul | - |
dc.contributor.alternativeName | Hur, Jin | - |
dc.contributor.alternativeName | Kim, Dae Joon | - |
dc.contributor.alternativeName | Kim, Joo Hang | - |
dc.contributor.alternativeName | Kim, Hyun Ki | - |
dc.contributor.affiliatedAuthor | Kim, Hye Ryun | - |
dc.contributor.affiliatedAuthor | Kim, Hyo Song | - |
dc.contributor.affiliatedAuthor | Park, Jun Chul | - |
dc.contributor.affiliatedAuthor | Shin, Sung Kwan | - |
dc.contributor.affiliatedAuthor | Lee, Sang Kil | - |
dc.contributor.affiliatedAuthor | Lee, Yong Chan | - |
dc.contributor.affiliatedAuthor | Lee, Chang Geol | - |
dc.contributor.affiliatedAuthor | Jung, Da Hyun | - |
dc.contributor.affiliatedAuthor | Cho, Byoung Chul | - |
dc.contributor.affiliatedAuthor | Hur, Jin | - |
dc.contributor.affiliatedAuthor | Kim, Dae Joon | - |
dc.contributor.affiliatedAuthor | Kim, Joo Hang | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Ki | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 6 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 2562 | - |
dc.citation.endPage | 2572 | - |
dc.identifier.bibliographicCitation | ONCOTARGET , Vol.6(4) : 2562-2572, 2015 | - |
dc.identifier.rimsid | 46581 | - |
dc.type.rims | ART | - |
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