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Fibroblast growth factor receptor 1 gene amplification is associated with poor survival in patients with resected esophageal squamous cell carcinoma.

DC FieldValueLanguage
dc.contributor.author김혜련-
dc.contributor.author김효송-
dc.contributor.author박준철-
dc.contributor.author신성관-
dc.contributor.author이상길-
dc.contributor.author이용찬-
dc.contributor.author이창걸-
dc.contributor.author정다현-
dc.contributor.author정현수-
dc.contributor.author조병철-
dc.contributor.author허진-
dc.contributor.author김대준-
dc.contributor.author김주항-
dc.contributor.author김현기-
dc.date.accessioned2016-02-04T11:10:09Z-
dc.date.available2016-02-04T11:10:09Z-
dc.date.issued2015-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139820-
dc.description.abstractTo investigate the frequency and the prognostic impact of fibroblast growth factor receptor 1 (FGFR1) gene amplification in 526 curatively resected esophageal squamous cell carcinoma (ESCC). Using fluorescent in situ hybridization, high amplification was defined by an FGFR1/centromer 8 ratio is ≥ 2.0, or average number of FGFR1 signals/tumor cell nucleus ≥ 6.0, or percentage of tumor cells containing ≥ 15 FGFR1 signals or large cluster in ≥ 10%. Low amplification was defined by ≥ 5 FGFR1 signals in ≥ 50%. FGFR2 and FGFR3 mutations were assessed by direct sequencing in 388 cases and no mutation was detected. High and low amplification were detected in 8.6% and 1.1%, respectively. High FGFR1 amplification had significantly shorter disease-free survival (34.0 vs 158.5 months P=0.019) and overall survival (52.2 vs not reached P=0.022) than low/no amplification group. After adjusting for sex, smoking, stage, histology, and adjuvant treatment, high FGFR1 amplification had a greater risk of recurrence (adjusted hazard ratio [AHR], 1.6; P=0.029) and death (AHR, 1.53; P=0.050). High amplification was significantly higher in current smokers than former and never-smokers (Ptrend<0.001) and increased proportional to smoking dosage. High FGFR1 amplification is a frequent oncogenic alteration and an independent poor prognostic factor in resected ESCC.-
dc.description.statementOfResponsibilityopen-
dc.format.extent2562~2572-
dc.relation.isPartOfONCOTARGET-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCarcinoma, Squamous Cell/genetics*-
dc.subject.MESHCarcinoma, Squamous Cell/pathology-
dc.subject.MESHCarcinoma, Squamous Cell/therapy-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHEsophageal Neoplasms/genetics*-
dc.subject.MESHEsophageal Neoplasms/pathology-
dc.subject.MESHEsophageal Neoplasms/therapy-
dc.subject.MESHFemale-
dc.subject.MESHGene Amplification*-
dc.subject.MESHHumans-
dc.subject.MESHIn Situ Hybridization, Fluorescence-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Recurrence, Local-
dc.subject.MESHPrognosis-
dc.subject.MESHReceptor, Fibroblast Growth Factor, Type 1/genetics*-
dc.subject.MESHRisk Factors-
dc.subject.MESHSmoking-
dc.titleFibroblast growth factor receptor 1 gene amplification is associated with poor survival in patients with resected esophageal squamous cell carcinoma.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHyo Song Kim-
dc.contributor.googleauthorSeung Eun Lee-
dc.contributor.googleauthorYoon Sung Bae-
dc.contributor.googleauthorDae Joon Kim-
dc.contributor.googleauthorChang‑Geol Lee-
dc.contributor.googleauthorJin Hur-
dc.contributor.googleauthorHyunsoo Chung-
dc.contributor.googleauthorJun Chul Park-
dc.contributor.googleauthorDa Hyun Jung-
dc.contributor.googleauthorSung Kwan Shin-
dc.contributor.googleauthorSang Kil Lee-
dc.contributor.googleauthorYong Chan Lee-
dc.contributor.googleauthorHye Ryun Kim-
dc.contributor.googleauthorYong Wha Moon-
dc.contributor.googleauthorJoo Hang Kim-
dc.contributor.googleauthorYoung Mog Shim-
dc.contributor.googleauthorSusan S. Jewell-
dc.contributor.googleauthorHyunki Kim-
dc.contributor.googleauthorYoon-La Choi-
dc.contributor.googleauthorByoung Chul Cho-
dc.identifier.doi10.18632/oncotarget.2944-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01166-
dc.contributor.localIdA01202-
dc.contributor.localIdA01676-
dc.contributor.localIdA02112-
dc.contributor.localIdA02812-
dc.contributor.localIdA02988-
dc.contributor.localIdA03240-
dc.contributor.localIdA03591-
dc.contributor.localIdA03822-
dc.contributor.localIdA04370-
dc.contributor.localIdA00368-
dc.contributor.localIdA00945-
dc.contributor.localIdA01108-
dc.relation.journalcodeJ02421-
dc.identifier.eissn1949-2553-
dc.identifier.pmid25537505-
dc.subject.keywordFibroblast growth factor receptor 1-
dc.subject.keywordesophageal squamous cell carcinoma-
dc.subject.keywordgene amplification-
dc.subject.keywordfluorescent in situ hybridization-
dc.subject.keywordprognostic factor-
dc.contributor.alternativeNameKim, Hye Ryun-
dc.contributor.alternativeNameKim, Hyo Song-
dc.contributor.alternativeNamePark, Jun Chul-
dc.contributor.alternativeNameShin, Sung Kwan-
dc.contributor.alternativeNameLee, Sang Kil-
dc.contributor.alternativeNameLee, Yong Chan-
dc.contributor.alternativeNameLee, Chang Geol-
dc.contributor.alternativeNameJung, Da Hyun-
dc.contributor.alternativeNameChung, Hyun Soo-
dc.contributor.alternativeNameCho, Byoung Chul-
dc.contributor.alternativeNameHur, Jin-
dc.contributor.alternativeNameKim, Dae Joon-
dc.contributor.alternativeNameKim, Joo Hang-
dc.contributor.alternativeNameKim, Hyun Ki-
dc.contributor.affiliatedAuthorKim, Hye Ryun-
dc.contributor.affiliatedAuthorKim, Hyo Song-
dc.contributor.affiliatedAuthorPark, Jun Chul-
dc.contributor.affiliatedAuthorShin, Sung Kwan-
dc.contributor.affiliatedAuthorLee, Sang Kil-
dc.contributor.affiliatedAuthorLee, Yong Chan-
dc.contributor.affiliatedAuthorLee, Chang Geol-
dc.contributor.affiliatedAuthorJung, Da Hyun-
dc.contributor.affiliatedAuthorCho, Byoung Chul-
dc.contributor.affiliatedAuthorHur, Jin-
dc.contributor.affiliatedAuthorKim, Dae Joon-
dc.contributor.affiliatedAuthorKim, Joo Hang-
dc.contributor.affiliatedAuthorKim, Hyun Ki-
dc.rights.accessRightsfree-
dc.citation.volume6-
dc.citation.number4-
dc.citation.startPage2562-
dc.citation.endPage2572-
dc.identifier.bibliographicCitationONCOTARGET , Vol.6(4) : 2562-2572, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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