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Incorporation of radiotherapy in the multidisciplinary treatment of isolated retroperitoneal lymph node recurrence from colorectal cancer

DC Field Value Language
dc.contributor.author신상준-
dc.contributor.author안중배-
dc.contributor.author이정심-
dc.contributor.author임준석-
dc.contributor.author금기창-
dc.contributor.author금웅섭-
dc.contributor.author김남규-
dc.contributor.author김태일-
dc.contributor.author장지석-
dc.date.accessioned2016-02-04T11:09:20Z-
dc.date.available2016-02-04T11:09:20Z-
dc.date.issued2015-
dc.identifier.issn1068-9265-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139789-
dc.description.abstractPURPOSE: This article was designed to study the clinical outcomes and prognostic factors following radiotherapy (RT) in the multidisciplinary management of isolated retroperitoneal lymph node (RPLN) recurrence of colorectal cancer. METHODS: We identified 52 patients treated consecutively with tumor-directed RT for isolated RPLN recurrence. Twenty-five patients received upfront RT (Group 1). Twenty-seven patients received RT after systemic therapy. The deferred RT was administered either to locally controlled tumors (Group 2, n = 17) or to locally progressive tumors in RPLNs (Group 3, n = 10). RESULTS: The median overall survival and progression-free survival were 41 and 13 months, respectively, with a median follow-up time of 34 months. Survival was not significantly different among three groups. Local recurrence (32/52) was predominant and occurred earlier than distant metastasis (31/52). Two-thirds of the local recurrences (21/32) involved outfield recurrence, which was mostly in the cranial direction (15/21) from the upper margin of the RT volume. Repeated RT successfully salvaged a substantial number of patients. A shorter disease-free interval, low-dose radiation, and a tumor location above the renal vein were independent risk factors for local recurrence (all P < 0.05). A large gross tumor volume was an independent risk factor for distant metastasis (P = 0.037). No acute or late RT-related toxicity ≥ grade 3 occurred. CONCLUSIONS: Our analysis suggests that both upfront RT and deferred RT incorporated into multidisciplinary management are potentially effective treatment strategies. We found that gross tumor volume, tumor location, and disease-free interval are important prognostic factors and should be taken into consideration to decide the timing of RT.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1520~1526-
dc.relation.isPartOfANNALS OF SURGICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHColorectal Neoplasms/mortality-
dc.subject.MESHColorectal Neoplasms/pathology-
dc.subject.MESHColorectal Neoplasms/therapy*-
dc.subject.MESHCombined Modality Therapy-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHLymph Nodes/pathology*-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHNeoplasm Recurrence, Local/mortality-
dc.subject.MESHNeoplasm Recurrence, Local/pathology-
dc.subject.MESHNeoplasm Recurrence, Local/radiotherapy*-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHNeoplasms/drug therapy*-
dc.subject.MESHNeoplasms/pathology-
dc.subject.MESHPrognosis-
dc.subject.MESHRetroperitoneal Neoplasms/mortality-
dc.subject.MESHRetroperitoneal Neoplasms/pathology-
dc.subject.MESHRetroperitoneal Neoplasms/radiotherapy*-
dc.subject.MESHSalvage Therapy*-
dc.subject.MESHSurvival Rate-
dc.titleIncorporation of radiotherapy in the multidisciplinary treatment of isolated retroperitoneal lymph node recurrence from colorectal cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJeongshim Lee-
dc.contributor.googleauthorJee Suk Chang-
dc.contributor.googleauthorSang Joon Shin-
dc.contributor.googleauthorJoon Seok Lim-
dc.contributor.googleauthorKi Chang Keum-
dc.contributor.googleauthorNam Kyu Kim-
dc.contributor.googleauthorJoong Bae Ahn-
dc.contributor.googleauthorTae Il Kim-
dc.contributor.googleauthorWoong Sub Koom-
dc.identifier.doi10.1245/s10434-014-4363-5-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02105-
dc.contributor.localIdA02262-
dc.contributor.localIdA03112-
dc.contributor.localIdA03408-
dc.contributor.localIdA00272-
dc.contributor.localIdA00273-
dc.contributor.localIdA00353-
dc.contributor.localIdA01079-
dc.contributor.localIdA04658-
dc.relation.journalcodeJ00179-
dc.identifier.eissn1534-4681-
dc.identifier.pmid25589152-
dc.identifier.urlhttp://link.springer.com/article/10.1245%2Fs10434-014-4363-5-
dc.subject.keywordOverall Survival-
dc.subject.keywordRenal Vein-
dc.subject.keywordClinical Target Volume-
dc.subject.keywordGross Tumor Volume-
dc.subject.keywordHelical Tomotherapy-
dc.contributor.alternativeNameShin, Sang Joon-
dc.contributor.alternativeNameAhn, Joong Bae-
dc.contributor.alternativeNameLee, Jeong Shim-
dc.contributor.alternativeNameLim, Joon Seok-
dc.contributor.alternativeNameKeum, Ki Chang-
dc.contributor.alternativeNameKoom, Woong Sub-
dc.contributor.alternativeNameKim, Nam Kyu-
dc.contributor.alternativeNameKim, Tae Il-
dc.contributor.affiliatedAuthorShin, Sang Joon-
dc.contributor.affiliatedAuthorAhn, Joong Bae-
dc.contributor.affiliatedAuthorLee, Jeong Shim-
dc.contributor.affiliatedAuthorLim, Joon Seok-
dc.contributor.affiliatedAuthorKeum, Ki Chang-
dc.contributor.affiliatedAuthorKoom, Woong Sub-
dc.contributor.affiliatedAuthorKim, Nam Kyu-
dc.contributor.affiliatedAuthorKim, Tae Il-
dc.rights.accessRightsnot free-
dc.citation.volume22-
dc.citation.number5-
dc.citation.startPage1520-
dc.citation.endPage1526-
dc.identifier.bibliographicCitationANNALS OF SURGICAL ONCOLOGY, Vol.22(5) : 1520-1526, 2015-
dc.identifier.rimsid53824-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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