Cited 20 times in
Fluorescent iodized emulsion for pre- and intraoperative sentinel lymph node imaging: validation in a preclinical model
DC Field | Value | Language |
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dc.contributor.author | 김세훈 | - |
dc.contributor.author | 김한솔 | - |
dc.contributor.author | 양재문 | - |
dc.contributor.author | 이상길 | - |
dc.contributor.author | 임준석 | - |
dc.contributor.author | 형우진 | - |
dc.date.accessioned | 2016-02-04T11:07:13Z | - |
dc.date.available | 2016-02-04T11:07:13Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0033-8419 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139708 | - |
dc.description.abstract | PURPOSE: To validate the usefulness of a newly developed tracer for preoperative gastric sentinel lymph node (LN) (SLN) mapping and intraoperative navigation after a single preoperative submucosal injection in rat and beagle models. MATERIALS AND METHODS: This study was approved by the Experimental Animal Ethical Committee of Yonsei University College of Medicine according to the eighth edition of the Guide for the Care and Use of Laboratory Animals published in 2011. An emulsion was developed that contained indocyanine green in iodized oil, which can be visualized with both computed tomography (CT) and near-infrared (NIR) optical imaging and has the property of delayed washout. This emulsion was injected into the footpad of rats (n = 6) and the gastric submucosa of beagles (n = 8). CT lymphography was performed. The degree of enhancement of popliteal LNs was measured in rats, and the enhancing LNs were identified and the degree of enhancement of the enhancing LNs was measured in beagles. Next, NIR imaging was performed in beagles during open, laparoscopic, and robotic surgery to identify LNs containing the fluorescent signals of indocyanine green. The enhanced LNs detected with CT lymphography and NIR imaging were matched to see if they corresponded. RESULTS: Preoperative CT lymphography facilitated SLN mapping, and 26 SLNs were identified in eight beagles. NIR imaging enabled high-spatial-resolution visualization of both SLNs and the intervening lymphatic vessels and was useful for intraoperative SLN navigation. CONCLUSION: SLN mapping with fluorescent iodized oil emulsion is effective and feasible for both CT and NIR imaging. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 196~204 | - |
dc.relation.isPartOf | RADIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Dogs | - |
dc.subject.MESH | Emulsions/chemistry | - |
dc.subject.MESH | Emulsions/pharmacokinetics* | - |
dc.subject.MESH | Ethiodized Oil/chemistry | - |
dc.subject.MESH | Ethiodized Oil/pharmacokinetics* | - |
dc.subject.MESH | Fluorescent Dyes | - |
dc.subject.MESH | Gastrectomy | - |
dc.subject.MESH | Hexoses/chemistry | - |
dc.subject.MESH | Hexoses/pharmacokinetics | - |
dc.subject.MESH | Intraoperative Care | - |
dc.subject.MESH | Laparoscopy | - |
dc.subject.MESH | Lymph Node Excision | - |
dc.subject.MESH | Lymphography/methods* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Polysorbates/chemistry | - |
dc.subject.MESH | Polysorbates/pharmacokinetics | - |
dc.subject.MESH | Radiographic Image Interpretation, Computer-Assisted | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Robotics | - |
dc.subject.MESH | Sentinel Lymph Node Biopsy* | - |
dc.subject.MESH | Stomach Neoplasms/diagnostic imaging | - |
dc.subject.MESH | Stomach Neoplasms/pathology* | - |
dc.subject.MESH | Stomach Neoplasms/surgery | - |
dc.subject.MESH | Surface-Active Agents/chemistry | - |
dc.subject.MESH | Surface-Active Agents/pharmacokinetics | - |
dc.subject.MESH | Tomography, X-Ray Computed/methods* | - |
dc.title | Fluorescent iodized emulsion for pre- and intraoperative sentinel lymph node imaging: validation in a preclinical model | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Honsoul Kim | - |
dc.contributor.googleauthor | Sang Kil Lee | - |
dc.contributor.googleauthor | Yoo Min Kim | - |
dc.contributor.googleauthor | Eun-Hye Lee | - |
dc.contributor.googleauthor | Soo-Jeong Lim | - |
dc.contributor.googleauthor | Se Hoon Kim | - |
dc.contributor.googleauthor | Jaemoon Yang | - |
dc.contributor.googleauthor | Joon Seok Lim | - |
dc.contributor.googleauthor | Woo Jin Hyung | - |
dc.identifier.doi | 10.1148/radiol.14141159 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00610 | - |
dc.contributor.localId | A01099 | - |
dc.contributor.localId | A02812 | - |
dc.contributor.localId | A03408 | - |
dc.contributor.localId | A04382 | - |
dc.contributor.localId | A02315 | - |
dc.relation.journalcode | J02596 | - |
dc.identifier.eissn | 1527-1315 | - |
dc.identifier.pmid | 25474180 | - |
dc.identifier.url | http://pubs.rsna.org/doi/abs/10.1148/radiol.14141159 | - |
dc.contributor.alternativeName | Kim, Se Hoon | - |
dc.contributor.alternativeName | Kim, Hon Soul | - |
dc.contributor.alternativeName | Yang, Jae Moon | - |
dc.contributor.alternativeName | Lee, Sang Kil | - |
dc.contributor.alternativeName | Lim, Joon Seok | - |
dc.contributor.alternativeName | Hyung, Woo Jin | - |
dc.contributor.affiliatedAuthor | Kim, Se Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Hon Soul | - |
dc.contributor.affiliatedAuthor | Lee, Sang Kil | - |
dc.contributor.affiliatedAuthor | Lim, Joon Seok | - |
dc.contributor.affiliatedAuthor | Hyung, Woo Jin | - |
dc.contributor.affiliatedAuthor | Yang, Jae Moon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 275 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 196 | - |
dc.citation.endPage | 204 | - |
dc.identifier.bibliographicCitation | RADIOLOGY, Vol.275(1) : 196-204, 2015 | - |
dc.identifier.rimsid | 52966 | - |
dc.type.rims | ART | - |
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