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The drug susceptibility profile and inducible resistance to macrolides of Mycobacterium abscessus and Mycobacterium massiliense in Korea

Authors
 Song Yee Kim  ;  Chang-Ki Kim  ;  Il Kwon Bae  ;  Seok Hoon Jeong  ;  Jae-Joon Yim  ;  Ji Ye Jung  ;  Moo Suk Park  ;  Young Sam Kim  ;  Se Kyu Kim  ;  Joon Chang  ;  Young Ae Kang 
Citation
 DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, Vol.81(2) : 107-111, 2015 
Journal Title
 DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE 
ISSN
 0732-8893 
Issue Date
2015
MeSH
Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/pharmacology* ; Female ; Humans ; Macrolides/pharmacology* ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Mycobacterium Infections, Nontuberculous/microbiology* ; Nontuberculous Mycobacteria/drug effects* ; Nontuberculous Mycobacteria/isolation & purification ; Republic of Korea ; Tertiary Care Centers ; Transcriptional Activation/drug effects* ; Young Adult
Keywords
In vitro susceptibility ; Inducible resistance ; Mycobacterium abscessus ; Mycobacterium massiliense
Abstract
We conducted drug susceptibility testing (DST) against various antimicrobial agents, including new candidate drugs, and investigated the relationship between inducible resistance (IR) to macrolides and erm(41) gene in Mycobacterium abscessus complex. Sixty-two isolates of M. abscessus complex from 2 tertiary care hospitals in South Korea were tested against 10 antimicrobial agents. Thirty-five isolates were M. abscessus, and 27 were Mycobacterium massiliense. Amikacin, moxifloxacin, linezolid, clofazimine, and tigecycline were active against most isolates and cefoxitin and ciprofloxacin against moderate number of isolates. M. massiliense remained susceptible to macrolides; in contrast, M. abscessus became highly resistant on day 14 after incubation. DST pattern did not differ between clarithromycin and azithromycin. IR to clarithromycin was correlated with erm(41) genotype in M. abscessus. Variations in susceptibility to antimicrobial agents within species and the difference in DST patterns between M. abscessus and M. massiliense suggest that DST and identification of M. abscessus complex are significant before treatment.
Full Text
http://www.sciencedirect.com/science/article/pii/S0732889314004167
DOI
10.1016/j.diagmicrobio.2014.10.007
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Young Ae(강영애) ORCID logo https://orcid.org/0000-0002-7783-5271
Kim, Se Kyu(김세규)
Kim, Song Yee(김송이) ORCID logo https://orcid.org/0000-0001-8627-486X
Kim, Young Sam(김영삼) ORCID logo https://orcid.org/0000-0001-9656-8482
Park, Moo Suk(박무석) ORCID logo https://orcid.org/0000-0003-0820-7615
Chang, Joon(장준) ORCID logo https://orcid.org/0000-0003-4542-6841
Jung, Ji Ye(정지예) ORCID logo https://orcid.org/0000-0003-1589-4142
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139701
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