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The drug susceptibility profile and inducible resistance to macrolides of Mycobacterium abscessus and Mycobacterium massiliense in Korea

DC FieldValueLanguage
dc.contributor.author강영애-
dc.contributor.author김세규-
dc.contributor.author김송이-
dc.contributor.author김영삼-
dc.contributor.author박무석-
dc.contributor.author장준-
dc.contributor.author정지예-
dc.date.accessioned2016-02-04T11:07:01Z-
dc.date.available2016-02-04T11:07:01Z-
dc.date.issued2015-
dc.identifier.issn0732-8893-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139701-
dc.description.abstractWe conducted drug susceptibility testing (DST) against various antimicrobial agents, including new candidate drugs, and investigated the relationship between inducible resistance (IR) to macrolides and erm(41) gene in Mycobacterium abscessus complex. Sixty-two isolates of M. abscessus complex from 2 tertiary care hospitals in South Korea were tested against 10 antimicrobial agents. Thirty-five isolates were M. abscessus, and 27 were Mycobacterium massiliense. Amikacin, moxifloxacin, linezolid, clofazimine, and tigecycline were active against most isolates and cefoxitin and ciprofloxacin against moderate number of isolates. M. massiliense remained susceptible to macrolides; in contrast, M. abscessus became highly resistant on day 14 after incubation. DST pattern did not differ between clarithromycin and azithromycin. IR to clarithromycin was correlated with erm(41) genotype in M. abscessus. Variations in susceptibility to antimicrobial agents within species and the difference in DST patterns between M. abscessus and M. massiliense suggest that DST and identification of M. abscessus complex are significant before treatment.-
dc.description.statementOfResponsibilityopen-
dc.format.extent107~111-
dc.relation.isPartOfDIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAnti-Bacterial Agents/pharmacology*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMacrolides/pharmacology*-
dc.subject.MESHMale-
dc.subject.MESHMicrobial Sensitivity Tests-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMycobacterium Infections, Nontuberculous/microbiology*-
dc.subject.MESHNontuberculous Mycobacteria/drug effects*-
dc.subject.MESHNontuberculous Mycobacteria/isolation & purification-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHTertiary Care Centers-
dc.subject.MESHTranscriptional Activation/drug effects*-
dc.subject.MESHYoung Adult-
dc.titleThe drug susceptibility profile and inducible resistance to macrolides of Mycobacterium abscessus and Mycobacterium massiliense in Korea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSong Yee Kim-
dc.contributor.googleauthorChang-Ki Kim-
dc.contributor.googleauthorIl Kwon Bae-
dc.contributor.googleauthorSeok Hoon Jeong-
dc.contributor.googleauthorJae-Joon Yim-
dc.contributor.googleauthorJi Ye Jung-
dc.contributor.googleauthorMoo Suk Park-
dc.contributor.googleauthorYoung Sam Kim-
dc.contributor.googleauthorSe Kyu Kim-
dc.contributor.googleauthorJoon Chang-
dc.contributor.googleauthorYoung Ae Kang-
dc.identifier.doi10.1016/j.diagmicrobio.2014.10.007-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00057-
dc.contributor.localIdA00602-
dc.contributor.localIdA00626-
dc.contributor.localIdA00707-
dc.contributor.localIdA01457-
dc.contributor.localIdA03472-
dc.contributor.localIdA03735-
dc.relation.journalcodeJ00731-
dc.identifier.eissn1879-0070-
dc.identifier.pmid25467784-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0732889314004167-
dc.subject.keywordIn vitro susceptibility-
dc.subject.keywordInducible resistance-
dc.subject.keywordMycobacterium abscessus-
dc.subject.keywordMycobacterium massiliense-
dc.contributor.alternativeNameKang, Young Ae-
dc.contributor.alternativeNameKim, Se Kyu-
dc.contributor.alternativeNameKim, Song Yi-
dc.contributor.alternativeNameKim, Young Sam-
dc.contributor.alternativeNamePark, Moo Suk-
dc.contributor.alternativeNameChang, Joon-
dc.contributor.alternativeNameJung, Ji Ye-
dc.contributor.affiliatedAuthorKang, Young Ae-
dc.contributor.affiliatedAuthorKim, Se Kyu-
dc.contributor.affiliatedAuthorKim, Song Yi-
dc.contributor.affiliatedAuthorKim, Young Sam-
dc.contributor.affiliatedAuthorPark, Moo Suk-
dc.contributor.affiliatedAuthorChang, Joon-
dc.contributor.affiliatedAuthorJung, Ji Ye-
dc.rights.accessRightsnot free-
dc.citation.volume81-
dc.citation.number2-
dc.citation.startPage107-
dc.citation.endPage111-
dc.identifier.bibliographicCitationDIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, Vol.81(2) : 107-111, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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