180 450

Cited 26 times in

Is metabolic syndrome predictive of prevalence, extent, and risk of coronary artery disease beyond its components? Results from the multinational coronary CT angiography evaluation for clinical outcome: an international multicenter registry (CONFIRM)

Authors
 Amir Ahmadi  ;  Jonathon Leipsic  ;  Gudrun Feuchtner  ;  Heidi Gransar  ;  Dan Kalra  ;  Ran Heo  ;  Stephan Achenbach  ;  Daniele Andreini  ;  Mouaz Al-Mallah  ;  Daniel S. Berman  ;  Matthew Budoff  ;  Filippo Cademartiri  ;  Tracy Q. Callister  ;  Hyuk-Jae Chang  ;  Kavitha Chinnaiyan  ;  Benjamin Chow  ;  Ricardo C. Cury  ;  Augustin Delago  ;  Millie J. Gomez  ;  Martin Hadamitzky  ;  Joerg Hausleiter  ;  Niree Hindoyan  ;  Philipp A. Kaufmann  ;  Yong-Jin Kim  ;  Fay Lin  ;  Erica Maffei  ;  Gianluca Pontone  ;  Gilbert L. Raff  ;  Leslee J. Shaw  ;  Todd C. Villines  ;  Allison Dunning  ;  James K. Min 
Citation
 PLOS ONE, Vol.10(3) : e0118998, 2015 
Journal Title
PLOS ONE
Issue Date
2015
MeSH
Acute Coronary Syndrome/complications ; Acute Coronary Syndrome/diagnosis* ; Acute Coronary Syndrome/diagnostic imaging ; Acute Coronary Syndrome/mortality ; Aged ; Angioplasty ; Cohort Studies ; Coronary Angiography ; Coronary Artery Disease/complications ; Coronary Artery Disease/diagnosis* ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/mortality ; Female ; Humans ; International Cooperation ; Male ; Metabolic Syndrome/complications ; Metabolic Syndrome/diagnosis* ; Metabolic Syndrome/diagnostic imaging ; Metabolic Syndrome/mortality ; Middle Aged ; Myocardial Infarction/complications ; Myocardial Infarction/diagnosis* ; Myocardial Infarction/diagnostic imaging ; Myocardial Infarction/mortality ; Prevalence ; Prognosis ; Registries* ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Survival Analysis ; Tomography, X-Ray Computed
Abstract
Although metabolic syndrome is associated with increased risk of cardiovascular disease and events, its added prognostic value beyond its components remains unknown. This study compared the prevalence, severity of coronary artery disease (CAD), and prognosis of patients with metabolic syndrome to those with individual metabolic syndrome components. The study cohort consisted of 27125 consecutive individuals who underwent ≥ 64-detector row coronary CT angiography (CCTA) at 12 centers from 2003 to 2009. Metabolic syndrome was defined as per NCEP/ATP III criteria. Metabolic syndrome patients (n = 690) were matched 1:1:1 to those with 1 component (n = 690) and 2 components (n = 690) of metabolic syndrome for age, sex, smoking status, and family history of premature CAD using propensity scoring. Major adverse cardiac events (MACE) were defined by a composite of myocardial infarction (MI), acute coronary syndrome, mortality and late target vessel revascularization. Patients with 1 component of metabolic syndrome manifested lower rates of obstructive 1-, 2-, and 3-vessel/left main disease compared to metabolic syndrome patients (9.4% vs 13.8%, 2.6% vs 4.5%, and 1.0% vs 2.3%, respectively; p < 0.05), while those with 2 components did not (10.5% vs 13.8%, 2.8% vs 4.5% and 1.3% vs 2.3%, respectively; p > 0.05). At 2.5 years, metabolic syndrome patients experienced a higher rate of MACE compared to patients with 1 component (4.4% vs 1.6%; p = 0.002), while no difference observed compared to individuals with 2 components (4.4% vs 3.2% p = 0.25) of metabolic syndrome. In conclusion, Metabolic syndrome patients have significantly greater prevalence, severity, and prognosis of CAD compared to patients with 1 but not 2 components of metabolic syndrome.
Files in This Item:
T201500740.pdf Download
DOI
10.1371/journal.pone.0118998
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Chang, Hyuk-Jae(장혁재) ORCID logo https://orcid.org/0000-0002-6139-7545
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139651
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links