Cited 27 times in
Is metabolic syndrome predictive of prevalence, extent, and risk of coronary artery disease beyond its components? Results from the multinational coronary CT angiography evaluation for clinical outcome: an international multicenter registry (CONFIRM)
DC Field | Value | Language |
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dc.contributor.author | 장혁재 | - |
dc.date.accessioned | 2016-02-04T11:05:42Z | - |
dc.date.available | 2016-02-04T11:05:42Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139651 | - |
dc.description.abstract | Although metabolic syndrome is associated with increased risk of cardiovascular disease and events, its added prognostic value beyond its components remains unknown. This study compared the prevalence, severity of coronary artery disease (CAD), and prognosis of patients with metabolic syndrome to those with individual metabolic syndrome components. The study cohort consisted of 27125 consecutive individuals who underwent ≥ 64-detector row coronary CT angiography (CCTA) at 12 centers from 2003 to 2009. Metabolic syndrome was defined as per NCEP/ATP III criteria. Metabolic syndrome patients (n = 690) were matched 1:1:1 to those with 1 component (n = 690) and 2 components (n = 690) of metabolic syndrome for age, sex, smoking status, and family history of premature CAD using propensity scoring. Major adverse cardiac events (MACE) were defined by a composite of myocardial infarction (MI), acute coronary syndrome, mortality and late target vessel revascularization. Patients with 1 component of metabolic syndrome manifested lower rates of obstructive 1-, 2-, and 3-vessel/left main disease compared to metabolic syndrome patients (9.4% vs 13.8%, 2.6% vs 4.5%, and 1.0% vs 2.3%, respectively; p < 0.05), while those with 2 components did not (10.5% vs 13.8%, 2.8% vs 4.5% and 1.3% vs 2.3%, respectively; p > 0.05). At 2.5 years, metabolic syndrome patients experienced a higher rate of MACE compared to patients with 1 component (4.4% vs 1.6%; p = 0.002), while no difference observed compared to individuals with 2 components (4.4% vs 3.2% p = 0.25) of metabolic syndrome. In conclusion, Metabolic syndrome patients have significantly greater prevalence, severity, and prognosis of CAD compared to patients with 1 but not 2 components of metabolic syndrome. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | e0118998 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acute Coronary Syndrome/complications | - |
dc.subject.MESH | Acute Coronary Syndrome/diagnosis* | - |
dc.subject.MESH | Acute Coronary Syndrome/diagnostic imaging | - |
dc.subject.MESH | Acute Coronary Syndrome/mortality | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Angioplasty | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Coronary Angiography | - |
dc.subject.MESH | Coronary Artery Disease/complications | - |
dc.subject.MESH | Coronary Artery Disease/diagnosis* | - |
dc.subject.MESH | Coronary Artery Disease/diagnostic imaging | - |
dc.subject.MESH | Coronary Artery Disease/mortality | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | International Cooperation | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Metabolic Syndrome/complications | - |
dc.subject.MESH | Metabolic Syndrome/diagnosis* | - |
dc.subject.MESH | Metabolic Syndrome/diagnostic imaging | - |
dc.subject.MESH | Metabolic Syndrome/mortality | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Myocardial Infarction/complications | - |
dc.subject.MESH | Myocardial Infarction/diagnosis* | - |
dc.subject.MESH | Myocardial Infarction/diagnostic imaging | - |
dc.subject.MESH | Myocardial Infarction/mortality | - |
dc.subject.MESH | Prevalence | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Registries* | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.subject.MESH | Survival Analysis | - |
dc.subject.MESH | Tomography, X-Ray Computed | - |
dc.title | Is metabolic syndrome predictive of prevalence, extent, and risk of coronary artery disease beyond its components? Results from the multinational coronary CT angiography evaluation for clinical outcome: an international multicenter registry (CONFIRM) | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Amir Ahmadi | - |
dc.contributor.googleauthor | Jonathon Leipsic | - |
dc.contributor.googleauthor | Gudrun Feuchtner | - |
dc.contributor.googleauthor | Heidi Gransar | - |
dc.contributor.googleauthor | Dan Kalra | - |
dc.contributor.googleauthor | Ran Heo | - |
dc.contributor.googleauthor | Stephan Achenbach | - |
dc.contributor.googleauthor | Daniele Andreini | - |
dc.contributor.googleauthor | Mouaz Al-Mallah | - |
dc.contributor.googleauthor | Daniel S. Berman | - |
dc.contributor.googleauthor | Matthew Budoff | - |
dc.contributor.googleauthor | Filippo Cademartiri | - |
dc.contributor.googleauthor | Tracy Q. Callister | - |
dc.contributor.googleauthor | Hyuk-Jae Chang | - |
dc.contributor.googleauthor | Kavitha Chinnaiyan | - |
dc.contributor.googleauthor | Benjamin Chow | - |
dc.contributor.googleauthor | Ricardo C. Cury | - |
dc.contributor.googleauthor | Augustin Delago | - |
dc.contributor.googleauthor | Millie J. Gomez | - |
dc.contributor.googleauthor | Martin Hadamitzky | - |
dc.contributor.googleauthor | Joerg Hausleiter | - |
dc.contributor.googleauthor | Niree Hindoyan | - |
dc.contributor.googleauthor | Philipp A. Kaufmann | - |
dc.contributor.googleauthor | Yong-Jin Kim | - |
dc.contributor.googleauthor | Fay Lin | - |
dc.contributor.googleauthor | Erica Maffei | - |
dc.contributor.googleauthor | Gianluca Pontone | - |
dc.contributor.googleauthor | Gilbert L. Raff | - |
dc.contributor.googleauthor | Leslee J. Shaw | - |
dc.contributor.googleauthor | Todd C. Villines | - |
dc.contributor.googleauthor | Allison Dunning | - |
dc.contributor.googleauthor | James K. Min | - |
dc.identifier.doi | 10.1371/journal.pone.0118998 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03490 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 25734639 | - |
dc.contributor.alternativeName | Chang, Hyuck Jae | - |
dc.contributor.affiliatedAuthor | Chang, Hyuck Jae | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 10 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | e0118998 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.10(3) : e0118998, 2015 | - |
dc.identifier.rimsid | 52383 | - |
dc.type.rims | ART | - |
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