1 220

Cited 3 times in

Relationship between serum γ-glutamyltransferase level and leukocyte count in Korean children and adolescents

Authors
 Youn Ho Shin  ;  Ki Eun Kim  ;  Kyu-Earn Kim  ;  Yong-Jae Lee 
Citation
 Scandinavian Journal of Clinical & Laboratory Investigation, Vol.75(2) : 177-182, 2015 
Journal Title
 Scandinavian Journal of Clinical & Laboratory Investigation 
ISSN
 0036-5513 
Issue Date
2015
Abstract
BACKGROUND: Elevated γ-glutamyltransferase (GGT) is an important risk factor for cardiometabolic diseases, which may result from chronic low-grade inflammation. Leukocyte count is widely considered a marker of inflammation and is also an independent predictor of cardiometabolic diseases. This study aimed to determine the relationship between GGT and leukocyte count in a representative sample of Korean children and adolescents. METHODS: A nationwide cross-sectional study was conducted to examine the relationship between GGT and leukocyte count in 830 boys and 714 girls (aged 10-18 years), using data from the 2010-2012 Korean National Health and Nutrition Examination Survey. The odds ratios (ORs) and 95% confidence intervals (CIs) for high leukocyte count (≥ 75th percentile) were calculated across GGT quartiles using multiple logistic regression analyses. RESULTS: Leukocyte count gradually increased in accordance with serum GGT quartiles in both boys and girls (all p-values < 0.001). The OR (95% CI) for high leukocyte of the highest GGT quartile was 2.19 (1.05-4.58) for boys and 2.36 (1.13-4.93) for girls after adjusting for age, BMI, blood pressure, total cholesterol, triglyceride, physical activity, household income, and residential area. Similarly, these positive associations were observed in multiple logistic regression analysis using log2-transformed serum GGT as a continuous variable. CONCLUSIONS: The present study demonstrates a positive relationship between serum GGT and leukocyte count. These findings indicate that serum GGT may be closely related with subclinical low-grade inflammation in children and adolescents.
Full Text
http://www.tandfonline.com/doi/abs/10.3109/00365513.2014.993693
DOI
10.3109/00365513.2014.993693
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
김규언(Kim, Kyu Earn)
김기은(Kim, Ki Eun)
이용제(Lee, Yong Jae) ORCID logo https://orcid.org/0000-0002-6697-476X
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139626
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse