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The effect of dexmedetomidine on intraocular pressure increase in patients during robot-assisted laparoscopic radical prostatectomy in the steep Trendelenburg position

 Na Young Kim  ;  Young Chul Yoo  ;  Hee Joon Park  ;  Young Deuk Choi  ;  Chan Yun Kim  ;  Sun Joon Bai 
 JOURNAL OF ENDOUROLOGY, Vol.29(3) : 310-316, 2015 
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Adult ; Anesthesia, General ; Dexmedetomidine/administration & dosage ; Dexmedetomidine/pharmacology* ; Female ; Head-Down Tilt* ; Humans ; Hypnotics and Sedatives/administration & dosage ; Hypnotics and Sedatives/pharmacology* ; Infusions, Intravenous ; Intraocular Pressure/drug effects* ; Laparoscopy/methods ; Male ; Middle Aged ; Prostatectomy/methods* ; Robotics/methods ; Treatment Outcome
PURPOSE: This study was to evaluate the effect of intraoperative continuous infusion of dexmedetomidine on intraocular pressure (IOP) in patients undergoing robot-assisted laparoscopic radical prostatectomy (RALRP) in the steep Trendelenburg (ST). MATERIALS AND METHODS: Sixty-eight patients were randomly divided into two groups. The dexmedetomidine group (Group D, n=34) received a continuous infusion of dexmedetomidine at a rate of 0.4 μg kg(-1) hour(-1) from the induction of anesthesia until the end of the ST position, while the control group (Group C, n=34) received an equal volume of physiologic saline at the same rate under conventional general anesthesia with sevoflurane and remifentanil. IOP was measured at 11 predefined time points for all patients. RESULTS: Significant differences in IOP were detected between the two groups by a linear mixed model analysis (p<0.001). The highest mean IOP was 19.9±5.0 mm Hg in Group D and 25.7±5.0 mm Hg in Group C; both were measured 60 minutes after the patients had been placed in the ST position. No significant between-group differences in ocular perfusion pressure, mean blood pressure, or heart rate were observed between the two groups. No ocular or other complications were noted. CONCLUSION: Intraoperative continuous infusion of dexmedetomidine may help alleviate IOP increase in patients undergoing RALRP in the ST position.
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Na Young(김나영) ORCID logo https://orcid.org/0000-0003-3685-2005
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
Bai, Sun Joon(배선준) ORCID logo https://orcid.org/0000-0001-5027-3232
Yoo, Young Chul(유영철) ORCID logo https://orcid.org/0000-0002-6334-7541
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
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