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Differential expression of lipid metabolism-related proteins in different breast cancer subtypes

Authors
 Sewha Kim  ;  YuKyung Lee  ;  Ja Seung Koo 
Citation
 PLOS ONE, Vol.10(3) : e119473, 2015 
Journal Title
PLOS ONE
Issue Date
2015
MeSH
Breast Neoplasms/metabolism* ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Female ; Gene Expression ; Gene Expression Regulation, Neoplastic ; Humans ; Kaplan-Meier Estimate ; Lipid Metabolism/genetics* ; Middle Aged ; Multivariate Analysis ; Neoplasm Grading ; Proportional Hazards Models
Abstract
PURPOSE: This study aimed to determine the expression and clinical significance of proteins that are involved in lipid metabolism in human breast tumors.
METHODS: Tumors from 476 breast cancer patients were used to construct tissue microarrays. Then, immunohistochemistry (IHC) for hormone-sensitive lipase (HSL), Perilipin 1 (PLIN1), fatty acid binding protein 4 (FABP4), carnitine palmitoyltransferase IA (CPT-1A), acyl-CoA oxidase 1 (ACOX-1), and fatty acid synthase (FASN) was performed on these microarrays.
RESULTS: Breast tumors were classified into 4 subtypes: luminal A (n = 242; 50.8%), luminal B (n = 134; 28.2%), human epidermal growth factor receptor 2 (HER2) (n = 50; 10.5%), and triple negative breast cancer (TNBC) (n = 50; 10.5%). The expression of PLIN1 (p < 0.001), FABP4 (p = 0.029), CPT-1A (p = 0.001), ACOX-1 (p < 0.001), and FASN (p < 0.001) differed significantly among these tumor subtypes. Notably, PLIN1, CPT-1A, and FASN expression was highest in HER2 tumors and lowest in TNBC tumors. Similarly, the expression of FABP4 and ACOX-1 was highest in HER2 tumors and lowest in luminal A tumors. In addition, ACOX-1 positivity was associated with significantly shorter overall survival (p = 0.018). When tumor subtype was considered, FABP4 positivity was associated with significantly shorter disease-free survival (p = 0.005) and overall survival (p = 0.041) in TNBC.
CONCLUSION: Lipid metabolism-related proteins are differentially expressed in different IHC subtypes of breast cancer and some are associated with decreased survival rates.
Files in This Item:
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DOI
10.1371/journal.pone.0119473
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Seung(구자승) ORCID logo https://orcid.org/0000-0003-4546-4709
Lee, Yu Kyung(이유경)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139592
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