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Long-term result of maintenance treatment with tacrolimus ointment in chronic ocular graft-versus-host disease

DC Field Value Language
dc.contributor.author김응권-
dc.contributor.author김태임-
dc.contributor.author서경률-
dc.contributor.author윤상철-
dc.contributor.author정지원-
dc.date.accessioned2016-02-04T11:01:27Z-
dc.date.available2016-02-04T11:01:27Z-
dc.date.issued2015-
dc.identifier.issn0002-9394-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139494-
dc.description.abstractPURPOSE: To investigate the efficacy and safety of long-term maintenance treatment with tacrolimus ointment in chronic ocular graft-vs-host disease (GVHD) with ocular surface inflammation. DESIGN: A retrospective interventional consecutive case series. METHOD: Long-term maintenance treatment (≥6 months) with topical 0.02% tacrolimus ointment was applied to patients with chronic ocular GVHD with ocular surface inflammation (at least grade 2 inflammatory score). We evaluated the inflammatory score, steroid score and steroid use period of total duration, and numbers of inflammatory aggravations before and after tacrolimus treatment. The clinical outcomes were assessed by symptom score, ocular surface staining, Schirmer I test, tear break-up time (TBUT), and classification of chronic GVHD conjunctivitis at the initial and final examinations. RESULTS: Thirteen patients (24 eyes) were treated with tacrolimus ointment for up to 20 months (average 12.2 months). The ocular surface inflammatory score decreased from 2.8 to 0.6 (P = .001) within 2-8 weeks after starting tacrolimus ointment treatment. The numbers of inflammatory aggravation and the need for steroid treatment also decreased after initiating tacrolimus treatment. At the final follow-up, all patients reported improvement in clinical outcomes, compared to initial findings. Except for blurred vision or mild burning sensation, there were no reported side effects. CONCLUSION: Considering the chronic course of GVHD, long-term maintenance treatment with tacrolimus ointment could be useful and safe to locally treat ocular surface inflammation in chronic ocular GVHD.-
dc.description.statementOfResponsibilityopen-
dc.format.extent519~527-
dc.relation.isPartOfAMERICAN JOURNAL OF OPHTHALMOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHChild, Preschool-
dc.subject.MESHChronic Disease-
dc.subject.MESHConjunctivitis/diagnosis-
dc.subject.MESHConjunctivitis/drug therapy*-
dc.subject.MESHConjunctivitis/etiology-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHGraft vs Host Disease/diagnosis-
dc.subject.MESHGraft vs Host Disease/drug therapy*-
dc.subject.MESHGraft vs Host Disease/etiology-
dc.subject.MESHHematopoietic Stem Cell Transplantation/adverse effects-
dc.subject.MESHHumans-
dc.subject.MESHImmunosuppressive Agents/adverse effects-
dc.subject.MESHImmunosuppressive Agents/therapeutic use*-
dc.subject.MESHKeratitis/diagnosis-
dc.subject.MESHKeratitis/drug therapy*-
dc.subject.MESHKeratitis/etiology-
dc.subject.MESHLeukemia/therapy-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOintments-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTacrolimus/adverse effects-
dc.subject.MESHTacrolimus/therapeutic use*-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHVisual Acuity-
dc.subject.MESHYoung Adult-
dc.titleLong-term result of maintenance treatment with tacrolimus ointment in chronic ocular graft-versus-host disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학)-
dc.contributor.googleauthorJi Won Jung-
dc.contributor.googleauthorYoung Ji Lee-
dc.contributor.googleauthorSang Chul Yoon-
dc.contributor.googleauthorTae-im Kim-
dc.contributor.googleauthorEung Kweon Kim-
dc.contributor.googleauthorKyoung Yul Seo-
dc.identifier.doi10.1016/j.ajo.2014.11.035-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00831-
dc.contributor.localIdA01080-
dc.contributor.localIdA01870-
dc.contributor.localIdA02560-
dc.contributor.localIdA03736-
dc.relation.journalcodeJ00097-
dc.identifier.eissn1879-1891-
dc.identifier.pmid25498356-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0002939414007806-
dc.contributor.alternativeNameKim, Eung Kweon-
dc.contributor.alternativeNameKim, Tae Im-
dc.contributor.alternativeNameSeo, Kyuong Yul-
dc.contributor.alternativeNameYoon, Sang Chul-
dc.contributor.alternativeNameJung, Ji Won-
dc.contributor.affiliatedAuthorKim, Eung Kweon-
dc.contributor.affiliatedAuthorKim, Tae Im-
dc.contributor.affiliatedAuthorSeo, Kyuong Yul-
dc.contributor.affiliatedAuthorYoon, Sang Chul-
dc.contributor.affiliatedAuthorJung, Ji Won-
dc.rights.accessRightsnot free-
dc.citation.volume159-
dc.citation.number3-
dc.citation.startPage519-
dc.citation.endPage527-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF OPHTHALMOLOGY, Vol.159(3) : 519-527, 2015-
dc.identifier.rimsid55430-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Humanities and Social Sciences (인문사회의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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