Cited 51 times in
Discrimination between active and latent tuberculosis based on ratio of antigen-specific to mitogen-induced IP-10 production
DC Field | Value | Language |
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dc.contributor.author | 강영애 | - |
dc.contributor.author | 신성재 | - |
dc.contributor.author | 조상래 | - |
dc.contributor.author | 허윤경 | - |
dc.contributor.author | 이혜존 | - |
dc.date.accessioned | 2016-02-04T11:00:48Z | - |
dc.date.available | 2016-02-04T11:00:48Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0095-1137 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139472 | - |
dc.description.abstract | Mycobacterium tuberculosis is the major causative agent of tuberculosis (TB). The gamma interferon (IFN-γ) release assay (IGRA) has been widely used to diagnose TB by testing cell-mediated immune responses but has no capacity for distinguishing between active TB and latent TB infection (LTBI). This study aims to identify a parameter that will help to discriminate active TB and LTBI. Whole-blood samples from 33 active TB patients, 20 individuals with LTBI, and 26 non-TB controls were applied to the commercial IFN-γ release assay, QuantiFERON-TB Gold In-Tube, and plasma samples were analyzed for interleukin-2 (IL-2), IL-6, IL-8, IL-10, IL-13, tumor necrosis factor-alpha (TNF-α), IFN-γ, monokine induced by IFN-γ (MIG), interferon gamma inducible protein 10 (IP-10), interferon-inducible T cell alpha chemoattractant (I-TAC), and monocyte chemoattractant protein 1 (MCP-1) by using a commercial cytometric bead array. The Mycobacterium tuberculosis antigen-specific production of most of the assayed cytokines and chemokines was higher in the active TB than in the LTBI group. The mitogen-induced responses were lower in the active TB than in the LTBI group. When the ratio of TB-specific to mitogen-induced responses was calculated, IL-2, IL-6, IL-10, IL-13, TNF-α, IFN-γ, MIG, and IP-10 were more useful in discriminating active TB from LTBI. In particular, most patients showed higher IP-10 production to Mycobacterium tuberculosis antigens than to mitogen at the individual level, and the ratio for IP-10 was the strongest indicator of active infection versus LTBI with 93.9% sensitivity and 90% specificity. In conclusion, the ratio of the TB-specific to the mitogen-induced IP-10 responses showed the most promising accuracy for discriminating active TB versus LTBI and should be further studied to determine whether it can serve as a biomarker that might help clinicians administer appropriate treatments. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MICROBIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Antigens, Bacterial/immunology* | - |
dc.subject.MESH | Chemokine CXCL10/secretion* | - |
dc.subject.MESH | Diagnosis, Differential | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interferon-gamma Release Tests/methods* | - |
dc.subject.MESH | Leukocytes, Mononuclear/immunology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mitogens/metabolism* | - |
dc.subject.MESH | Mycobacterium tuberculosis/immunology* | - |
dc.subject.MESH | Tuberculosis/diagnosis* | - |
dc.subject.MESH | Young Adult | - |
dc.title | Discrimination between active and latent tuberculosis based on ratio of antigen-specific to mitogen-induced IP-10 production | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Yun Hee Jeong | - |
dc.contributor.googleauthor | Yun-Gyoung Hur | - |
dc.contributor.googleauthor | Hyejon Lee | - |
dc.contributor.googleauthor | Sunghyun Kim | - |
dc.contributor.googleauthor | Jang-Eun Cho | - |
dc.contributor.googleauthor | Jun Chang | - |
dc.contributor.googleauthor | Sung Jae Shin | - |
dc.contributor.googleauthor | Hyeyoung Lee | - |
dc.contributor.googleauthor | Young Ae Kang | - |
dc.contributor.googleauthor | Sang-Nae Cho | - |
dc.contributor.googleauthor | Sang-Jun Ha | - |
dc.identifier.doi | 10.1128/JCM.02758-14 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02114 | - |
dc.contributor.localId | A00057 | - |
dc.contributor.localId | A03824 | - |
dc.contributor.localId | A04701 | - |
dc.relation.journalcode | J01325 | - |
dc.identifier.eissn | 1098-660X | - |
dc.identifier.pmid | 25428147 | - |
dc.contributor.alternativeName | Kang, Young Ae | - |
dc.contributor.alternativeName | Shin, Sung Jae | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.contributor.alternativeName | Hur, Yun Gyoung | - |
dc.contributor.affiliatedAuthor | Shin, Sung Jae | - |
dc.contributor.affiliatedAuthor | Kang, Young Ae | - |
dc.contributor.affiliatedAuthor | Cho, Sang Nae | - |
dc.contributor.affiliatedAuthor | Hur, Yun-Gyoung | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 53 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 504 | - |
dc.citation.endPage | 510 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MICROBIOLOGY, Vol.53(2) : 504-510, 2015 | - |
dc.identifier.rimsid | 55416 | - |
dc.type.rims | ART | - |
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