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MicroRNAs are Potential Biomarkers and Therapeutic Targets of Atopic Dermatitis

Authors
 Won Suck Yoon  ;  Young Yoo  ;  Tae Ho Lee  ;  Sung Ha Park  ;  Byeong Mo Kim 
Citation
 Jacobs Journal of Allergy and Immunology, Vol.1(2) : 013, 2015 
Journal Title
 Jacobs Journal of Allergy and Immunology 
ISSN
 2376-9017 
Issue Date
2015
MeSH
Adaptive Immunity ; Animals ; Biological Therapy/trends* ; Biomarkers/metabolism ; Dermatitis, Atopic/diagnosis ; Dermatitis, Atopic/immunology* ; Humans ; Immunity, Innate ; MicroRNAs/metabolism* ; Psoriasis/diagnosis ; Psoriasis/immunology* ; Skin/immunology*
Keywords
allergic contact dermatitis ; atopic dermatitis ; biomarkers ; miRNAs ; non-coding RNA ; psoriasis
Abstract
microRNAs (miRNAs) are a class of small, non-coding RNAs that regulate the expression of a diverse array of genes and pathways, with important roles in disease pathogenesis. Many of these miRNAs are currently under investigation as biomarkers or therapeutic options in a range of diseases. Here, we discuss the role of miRNAs in atopic dermatitis, a relapsing chronic pruritic inflammatory skin disease of unknown etiology, as they have been strongly implicated in the pathogenesis of skin inflammation. We outline the history and application of miRNAs for the detection and treatment of atopic dermatitis in comparison with other diseases, such as cancer and cardiovascular disease, which may assist the development of diagnostic and therapeutic strategies.
Files in This Item:
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DOI
2015
Appears in Collections:
5. Research Institutes (연구소) > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Byeong Mo(김병모) ORCID logo https://orcid.org/0000-0002-0582-3132
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139466
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