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Serum HBV surface antigen positivity is associated with low prevalence of metabolic syndrome in Korean adult men

 Ja Sung Choi  ;  Ki Jun Han  ;  Sangheun Lee  ;  Song Wook Chun  ;  Dae Jung Kim  ;  Hyeon Chang Kim  ;  Hee Man Kim 
 JOURNAL OF EPIDEMIOLOGY, Vol.25(1) : 74-79, 2015 
Journal Title
Issue Date
Adult ; Female ; Hepatitis B Surface Antigens/blood* ; Humans ; Male ; Metabolic Syndrome/blood ; Metabolic Syndrome/epidemiology* ; Middle Aged ; Prevalence ; Republic of Korea/epidemiology ; Sex Distribution
chronic hepatitis B ; metabolic syndrome ; survey ; triglycerides
BACKGROUND: Metabolic syndrome has clinical implications for chronic liver disease, but the relationship between chronic hepatitis B and metabolic syndrome remains unclear. The aim of this study was to determine whether hepatitis B surface antigen (HBsAg) positivity is associated with metabolic syndrome. METHODS: Data were obtained from the Third Korean National Health and Nutrition Examination Survey (KNHANES). Participant sera were tested for HBsAg. Metabolic syndrome was defined according to the modified National Cholesterol Education Program Adult Treatment Panel III guidelines for Koreans. RESULTS: Of the 5108 participants, 209 (4.1%) tested positive for HBsAg, and 1364 (26.7%) were diagnosed with metabolic syndrome. The prevalence of metabolic syndrome was 23.4% in HBsAg-positive men, 31.5% in HBsAg-negative men, 18.6% in HBsAg-positive women, and 23.7% in HBsAg-negative women. After adjusting for multiple factors, male participants who tested positive for serum HBsAg had an odds ratio of 0.612 (95% confidence interval [CI] 0.375-0.998) for metabolic syndrome and an odds ratio of 0.631 (95% CI 0.404-0.986) for elevated triglycerides. Women who tested positive for serum HBsAg had an odds ratio of 0.343 (95% CI 0.170-0.693) for elevated triglycerides. CONCLUSIONS: Positive results for serum HBsAg are inversely associated with metabolic syndrome in men and with elevated triglycerides in men and women. This suggests that elevated triglycerides may contribute to the inverse association between HBsAg and metabolic syndrome.
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1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
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