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Comparison of efficacy and safety of levofloxacin-containing versus standard sequential therapy in eradication of Helicobacter pylori infection in Korea

Authors
 Hyuk Lee  ;  Sung Noh Hong  ;  Byung-Hoon Min  ;  Jun Haeng Lee  ;  Poong-Lyul Rhee  ;  Yong Chan Lee  ;  Jae J. Kim 
Citation
 DIGESTIVE AND LIVER DISEASE, Vol.47(2) : 114-118, 2015 
Journal Title
 DIGESTIVE AND LIVER DISEASE 
ISSN
 1590-8658 
Issue Date
2015
MeSH
Adult ; Amoxicillin/therapeutic use* ; Anti-Bacterial Agents/therapeutic use* ; Breath Tests ; Clarithromycin/therapeutic use* ; Drug Resistance, Bacterial ; Drug Therapy, Combination ; Female ; Helicobacter Infections/drug therapy* ; Helicobacter pylori ; Humans ; Levofloxacin/therapeutic use* ; Male ; Metronidazole/therapeutic use* ; Middle Aged ; Proton Pump Inhibitors/therapeutic use* ; Rabeprazole/therapeutic use* ; Republic of Korea ; Treatment Outcome ; Urea/analysis
Keywords
Eradication ; Helicobacter pylori ; Levofloxacin ; Sequential therapy
Abstract
BACKGROUND: Declining of eradication rates for Helicobacter pylori in Korea may be partly from the increasing prevalence of antibiotic resistance, especially clarithromycin resistance. AIM: To compare the efficacy and the safety of using 10-day standard sequential therapy and levofloxacin-containing sequential therapy as a first-line treatment for Helicobacter pylori eradication in Korea. METHODS: A total of 200 patients with proven Helicobacter pylori infection randomly received 10-day standard sequential therapy (n = 100) or levofloxacin-containing sequential therapy (n = 100). The standard sequential therapy group received rabeprazole and amoxicillin for 5 days, followed by rabeprazole, clarithromycin, and metronidazole for 5 more days. The levofloxacin-containing sequential therapy group was treated with rabeprazole and amoxicillin for 5 days, followed by rabeprazole, levofloxacin, and metronidazole for 5 more days. RESULTS: Intention-to-treat eradication rates were 79.0% and 78.0% for groups of standard sequential and levofloxacin-containing sequential therapy, respectively (P = 0.863). Per-protocol eradication rates were 84.9% and 81.3%, respectively, for these two therapies (P = 0.498). There were no significant differences between the groups in regard to the eradication rates and adverse events. CONCLUSIONS: The 10-day levofloxacin-containing sequential regimen and the standard sequential regimen showed the similar eradication rates of Helicobacter pylori in Korea.
Full Text
http://www.sciencedirect.com/science/article/pii/S1590865814007592
DOI
10.1016/j.dld.2014.10.014
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139318
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