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Comparison of efficacy and safety of levofloxacin-containing versus standard sequential therapy in eradication of Helicobacter pylori infection in Korea

DC Field Value Language
dc.contributor.author이용찬-
dc.date.accessioned2016-02-04T10:56:31Z-
dc.date.available2016-02-04T10:56:31Z-
dc.date.issued2015-
dc.identifier.issn1590-8658-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139318-
dc.description.abstractBACKGROUND: Declining of eradication rates for Helicobacter pylori in Korea may be partly from the increasing prevalence of antibiotic resistance, especially clarithromycin resistance. AIM: To compare the efficacy and the safety of using 10-day standard sequential therapy and levofloxacin-containing sequential therapy as a first-line treatment for Helicobacter pylori eradication in Korea. METHODS: A total of 200 patients with proven Helicobacter pylori infection randomly received 10-day standard sequential therapy (n = 100) or levofloxacin-containing sequential therapy (n = 100). The standard sequential therapy group received rabeprazole and amoxicillin for 5 days, followed by rabeprazole, clarithromycin, and metronidazole for 5 more days. The levofloxacin-containing sequential therapy group was treated with rabeprazole and amoxicillin for 5 days, followed by rabeprazole, levofloxacin, and metronidazole for 5 more days. RESULTS: Intention-to-treat eradication rates were 79.0% and 78.0% for groups of standard sequential and levofloxacin-containing sequential therapy, respectively (P = 0.863). Per-protocol eradication rates were 84.9% and 81.3%, respectively, for these two therapies (P = 0.498). There were no significant differences between the groups in regard to the eradication rates and adverse events. CONCLUSIONS: The 10-day levofloxacin-containing sequential regimen and the standard sequential regimen showed the similar eradication rates of Helicobacter pylori in Korea.-
dc.description.statementOfResponsibilityopen-
dc.format.extent114~118-
dc.relation.isPartOfDIGESTIVE AND LIVER DISEASE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAmoxicillin/therapeutic use*-
dc.subject.MESHAnti-Bacterial Agents/therapeutic use*-
dc.subject.MESHBreath Tests-
dc.subject.MESHClarithromycin/therapeutic use*-
dc.subject.MESHDrug Resistance, Bacterial-
dc.subject.MESHDrug Therapy, Combination-
dc.subject.MESHFemale-
dc.subject.MESHHelicobacter Infections/drug therapy*-
dc.subject.MESHHelicobacter pylori-
dc.subject.MESHHumans-
dc.subject.MESHLevofloxacin/therapeutic use*-
dc.subject.MESHMale-
dc.subject.MESHMetronidazole/therapeutic use*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProton Pump Inhibitors/therapeutic use*-
dc.subject.MESHRabeprazole/therapeutic use*-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHUrea/analysis-
dc.titleComparison of efficacy and safety of levofloxacin-containing versus standard sequential therapy in eradication of Helicobacter pylori infection in Korea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHyuk Lee-
dc.contributor.googleauthorSung Noh Hong-
dc.contributor.googleauthorByung-Hoon Min-
dc.contributor.googleauthorJun Haeng Lee-
dc.contributor.googleauthorPoong-Lyul Rhee-
dc.contributor.googleauthorYong Chan Lee-
dc.contributor.googleauthorJae J. Kim-
dc.identifier.doi10.1016/j.dld.2014.10.014-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02988-
dc.relation.journalcodeJ00735-
dc.identifier.eissn1878-3562-
dc.identifier.pmid25467826-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S1590865814007592-
dc.subject.keywordEradication-
dc.subject.keywordHelicobacter pylori-
dc.subject.keywordLevofloxacin-
dc.subject.keywordSequential therapy-
dc.contributor.alternativeNameLee, Yong Chan-
dc.contributor.affiliatedAuthorLee, Yong Chan-
dc.rights.accessRightsnot free-
dc.citation.volume47-
dc.citation.number2-
dc.citation.startPage114-
dc.citation.endPage118-
dc.identifier.bibliographicCitationDIGESTIVE AND LIVER DISEASE, Vol.47(2) : 114-118, 2015-
dc.identifier.rimsid45565-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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