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Effect of Korean Red Ginseng supplementation on dry eye syndrome in glaucoma patients - A randomized, double-blind, placebo-controlled study

Authors
 Hyoung Won Bae  ;  Ji Hyun Kim  ;  Sangah Kim  ;  Minkyo Kim  ;  Naeun Lee  ;  Samin Hong  ;  Gong Je Seong  ;  Chan Yun Kim 
Citation
 JOURNAL OF GINSENG RESEARCH, Vol.39(1) : 7-13, 2015 
Journal Title
 JOURNAL OF GINSENG RESEARCH 
ISSN
 1226-8453 
Issue Date
2015
Keywords
Korean Red Ginseng ; Panax ginseng ; dry eye syndrome ; glaucoma
Abstract
BACKGROUND: Many patients with glaucoma have difficulty using antiglaucoma eye drops because of dry eye symptom. In this prospective, randomized, double-blind, placebo-controlled study, we evaluated the effect of Korean Red Ginseng on dry eye syndrome in patients with glaucoma treated with antiglaucoma eye drops. METHODS: Forty-nine participants were allocated to the Korean Red Ginseng (3 g/day; n = 24) or placebo (n = 25) groups for 8 weeks. Tear film stability, fluorescein corneal staining, conjunctival hyperemia, tear production, grade of meibomian gland dysfunction, and dry eye questionnaire (Ocular Surface Disease Index) were evaluated at baseline and on completion of the treatment. RESULTS: Almost all patients displayed dry eye symptoms and signs at baseline. After the 8-week intervention, Korean Red Ginseng supplementation significantly improved the tear film stability and total Ocular Surface Disease Index score, as compared to placebo (p < 0.01). CONCLUSION: Korean Red Ginseng supplementation may provide an additional treatment option for dry eye and patients with glaucoma using antiglaucoma eye drops.
Files in This Item:
T201500209.pdf Download
DOI
10.1016/j.jgr.2014.07.002
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sangah(김상아) ORCID logo https://orcid.org/0000-0002-8511-2903
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
Bae, Hyoung Won(배형원) ORCID logo https://orcid.org/0000-0002-8421-5636
Seong, Gong Je(성공제) ORCID logo https://orcid.org/0000-0002-5456-4296
Hong, Sa Min(홍사민)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139278
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