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Histamine skin reactivity increases with body mass index in Korean children

Authors
 Ju Wan Kang  ;  Keun-Hwa Lee  ;  Seong-Chul Hong  ;  Hye-Sook Lee  ;  Jaechun Lee  ;  Chang-Hoon Kim  ;  Jeong Hong Kim 
Citation
 INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, Vol.79(2) : 111-114, 2015 
Journal Title
 INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY 
ISSN
 0165-5876 
Issue Date
2015
Keywords
Allergy ; Body mass index ; Children ; Histamine ; Skin prick test ; Skin reactivity
Abstract
OBJECTIVE: Histamine skin prick testing is most commonly used to diagnose immunoglobulin E (IgE)-mediated allergic diseases, and histamine reactivity is used as a standardized positive control in the interpretation of a skin prick test. However, reactivity to histamine differs among individuals for reasons that are poorly understood. The present study aimed to evaluate the potential association between body mass index (BMI) and histamine skin reactivity in children. METHODS: A total of 451 children (246 boys, 205 girls) aged 7-8 years were enrolled in this study. The skin prick test was performed with 26 aeroallergens commonly found in Korea. Other information was collected, including sex, age, BMI, parental allergy history, and parental smoking status. Multivariate analysis was used to confirm the association between histamine skin reactivity and BMI. RESULTS: The histamine wheal size was revealed to be associated with BMI (Spearman's Rho 0.161, p<0.001). This association was confirmed by multivariate analysis, after adjusting for sex, age, parental allergy history, parental smoking status, and allergic sensitization (coefficient B 0.071, 95% confidence interval 0.030-0.112). CONCLUSIONS: Skin responses to histamine were primarily correlated with increased BMI. Further studies are needed to understand the clinical implication of BMI when interpreting the results of skin prick test.
Full Text
http://www.sciencedirect.com/science/article/pii/S0165587614006107
DOI
10.1016/j.ijporl.2014.11.012
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Ju Wan(강주완)
Kim, Chang Hoon(김창훈) ORCID logo https://orcid.org/0000-0003-1238-6396
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139262
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