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Hemoglobin assay in anemic patients with a photothermal spectral-domain optical coherence reflectometric sensor

Authors
 Hun Kim  ;  Sungwook Song  ;  Jinyeong Yim  ;  Hyun Ok Kim  ;  Chulmin Joo 
Citation
 Clinica Chimica Acta, Vol.439 : 71-76, 2015 
Journal Title
 Clinica Chimica Acta 
ISSN
 0009-8981 
Issue Date
2015
Abstract
BACKGROUND: We recently introduced an optical sensor, termed photothermal spectral-domain optical coherence reflectometer (PT SD-OCR), capable of direct measurement of hemoglobin concentration ([Hb]) without chemicals and pre-processing of blood. PT SD-OCR measures [Hb] by quantifying refractive index changes of blood samples due to photothermal effect under the irradiation of 532-nm light. We evaluated diagnostic accuracy and precision of PT SD-OCR in anemic patients. METHODS: We used PT SD-OCR to measure [Hb] in 50 anemic patients, and examined its accuracy against a hematology analyzer (ADVIA 2120i, Siemens AG). Its precision was assessed by examining the SD and CV based on 20 repeated measurements on 3 blood samples. Its performance was also compared with a hemoglobinometer (HemoCue 201+, HemoCue). RESULTS: The PT SD-OCR demonstrated good correspondence with the hematology analyzer with a Pearson's correlation coefficient of 0.992 and a bias of -0.055 g/dl. Standard deviation and CV were measured to be <0.25 g/dl and <2.05%. CONCLUSIONS: Simple and chemical-free operation of PT SD-OCR enabled rapid and accurate measurement of [Hb] in anemic patients. The sensor is expected to facilitate clinical procedures related to blood-related disorders in patient care.
Full Text
http://www.sciencedirect.com/science/article/pii/S000989811400432X
DOI
10.1016/j.cca.2014.10.001
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
김현옥(Kim, Hyun Ok) ORCID logo https://orcid.org/0000-0002-4964-1963
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139235
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