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Follicular variant of papillary thyroid carcinoma with B-type RafV600E showing higher frequency of suspicious sonographic features and multifocality

 Dong Yeob Shin  ;  Kwang Joon Kim  ;  Eun Jig Lee  ;  Woong Youn Chung  ;  Sang Wook Kang  ;  Seulkee Park  ;  Jaehyun Bae  ;  Wonjin Kim  ;  Sena Hwang  ;  Hyunki Kim  ;  Sooyun Chang 
 Head & Neck, Vol.37(11) : 1590-1595, 2015 
Journal Title
 Head & Neck 
Issue Date
BACKGROUND: The purpose of this study was to investigate the correlation between B-type Raf (BRAF) kinase mutation and clinicopathological features of follicular variant of papillary thyroid carcinoma (PTC). METHODS: Eighty-four patients with pathologically confirmed follicular variant of PTC, who underwent a preoperative BRAF(V600E) study, were analyzed. Clinicopathological parameters and ultrasonographic features were compared between the BRAF(V600E) -positive and negative groups. RESULTS: A total of 41.7% of the patients showed BRAF(V600E) . The BRAF(V600E) -positive group showed the smaller tumor size (7.3 ± 3.6 mm vs 10.7 ± 8.9 mm; p = .018) and the more frequent multifocality (25.7% vs 8.2%; p = .028). Follicular variant of PTC with BRAF(V600E) showed suspicious ultrasonographic features (88.6% vs 57.1%; p = .002) more frequently. BRAF(V600E) positivity is associated with multifocality after adjusting for age, sex, the presence of suspicious ultrasonographic features, pathological tumor size, and thyrotropin level. CONCLUSION: BRAF(V600E) was correlated with smaller tumor size and suspicious ultrasonographic features in follicular variant of PTC. BRAF(V600E) was a significant parameter for predicting multifocality of follicular variant of PTC.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
강상욱(Kang, Sang Wook) ORCID logo https://orcid.org/0000-0001-5355-833X
김광준(Kim, Kwang Joon) ORCID logo https://orcid.org/0000-0002-5554-8255
김원진(Kim, Won Jin)
김현기(Kim, Hyunki) ORCID logo https://orcid.org/0000-0003-2292-5584
박슬기(Park, Seul Kee)
배재현(Bae, Jae Hyun) ORCID logo https://orcid.org/0000-0002-3462-890X
신동엽(Shin, Dong Yeob) ORCID logo https://orcid.org/0000-0003-1048-7978
이은직(Lee, Eun Jig) ORCID logo https://orcid.org/0000-0002-9876-8370
장수연(Chang, Soo Yun)
정웅윤(Chung, Woung Youn)
황세나(Hwang, Se Na)
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