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Apatite-coated collagen sponge for the delivery of bone morphogenetic protein-2 in rabbit posterolateral lumbar fusion

Authors
 Ki Hyoung Koo  ;  Jung Min Ahn  ;  Jong Min Lee  ;  Byung-Soo Kim  ;  Chang-Sung Kim  ;  Gun-Il Im 
Citation
 ARTIFICIAL ORGANS, Vol.38(10) : 893-899, 2014 
Journal Title
 ARTIFICIAL ORGANS 
ISSN
 0160-564X 
Issue Date
2014
MeSH
Animals ; Apatites* ; Bone Morphogenetic Protein 2/administration & dosage* ; Collagen* ; Lumbar Vertebrae/surgery* ; Male ; Models, Animal ; Rabbits ; Spinal Fusion/methods* ; Surgical Sponges*
Keywords
Apatite-coated collagen sponge ; Bone morphogenetic protein-2 ; Delivery system ; Spine fusion
Abstract
Bone morphogenetic proteins (BMPs) need an effective delivery system for efficient bone regeneration. In this study, we evaluated the efficiency of an apatite-coated collagen sponge for the long-term delivery of BMP-2 in a rabbit model of lumbar posterolateral fusion. A total of 15 rabbits, divided into three groups, underwent posterolateral lumbar fusion. The first group (control group) received uncoated collagen sponges without BMP-2. The second group (uncoated group) received uncoated collagen sponges with BMP-2 (40 μg each side). The third group (apatite-coated group) received apatite-coated collagen sponges with the same level of BMPs (40 μg each side). All rabbits were euthanized 6 weeks after operation, and the fusion status was assessed by radiographic study, micro-CT, manual palpation, biomechanical study, and histological examination. Fusion rates as determined by radiographic study, micro-CT, and manual palpation showed that the apatite-coated group had a significantly higher rate of fusion than the control group (P = 0.024), while the uncoated group did not (P = 0.083). Biomechanical study showed significantly higher tensile strength in the apatite-coated group than the uncoated group (P = 0.032). Denser trabeculations were found in the apatite-coated group compared with the uncoated group. It is concluded that the use of apatite-coated collagen sponges for BMP-2 delivery enhanced bone regeneration.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/aor.12249/abstract
DOI
10.1111/aor.12249
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139014
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