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Lymphatic vessel invasion and lymph node metastasis in patients with clinical stage I non-small cell lung cancer.

Authors
 Du Young Kang  ;  Sungsoo Lee 
Citation
 THORACIC AND CARDIOVASCULAR SURGEON, Vol.62(6) : 521-524, 2014 
Journal Title
 THORACIC AND CARDIOVASCULAR SURGEON 
ISSN
 0171-6425 
Issue Date
2014
MeSH
Adenocarcinoma/secondary* ; Adenocarcinoma/surgery ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Non-Small-Cell Lung/secondary* ; Carcinoma, Non-Small-Cell Lung/surgery ; Carcinoma, Squamous Cell/secondary* ; Carcinoma, Squamous Cell/surgery ; Female ; Humans ; Logistic Models ; Lung Neoplasms/pathology* ; Lung Neoplasms/surgery ; Lymph Node Excision ; Lymphatic Metastasis ; Lymphatic Vessels/pathology* ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Pneumonectomy/methods ; Republic of Korea ; Retrospective Studies ; Risk Factors ; Thoracic Surgery, Video-Assisted ; Thoracotomy
Keywords
Lymphatic vessel invasion ; non-small cell lung cancer ; lymph node metastasis
Abstract
BACKGROUND: The aim of this study was to investigate the association between the presence of lymphatic vessel invasion (LVI) in primary tumors and lymph node (LN) metastasis in clinical stage I non-small cell lung cancer (NSCLC) patients. MATERIALS AND METHODS: A total of 76 patients who underwent complete resection for clinical stage I adenocarcinoma and squamous cell carcinoma were retrospectively examined. RESULTS: Tumors consisted of 51 cases of adenocarcinoma and 25 cases of squamous cell carcinoma as determined by histology. LN metastasis was detected in 24.4% (19/76) of patients. Factors associated with LN metastasis on univariate analysis included LVI (p < 0.001) and increased tumor dimensions (p < 0.05). Binary logistic regression analysis showed that the presence of LVI (p < 0.001) was the only predictor of LN metastasis. CONCLUSION: LVI is significantly associated with LN metastasis in patients with clinical stage I NSCLC. These findings may be helpful in determining the most appropriate operative strategy for patients if preoperative detection of LVI becomes feasible.
Full Text
https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0034-1381744
DOI
10.1055/s-0034-1381744
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Sung Soo(이성수) ORCID logo https://orcid.org/0000-0001-8998-9510
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139002
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