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Staple line coverage after bullectomy for primary spontaneous pneumothorax: a randomized trial

 Sungsoo Lee  ;  Hyeong Ryul Kim  ;  Sukki Cho  ;  Dong Myung Huh  ;  Eung Bae Lee  ;  Kyoung Min Ryu  ;  Deug Gon Cho  ;  Hyo Chae Paik  ;  Dong Kwan Kim  ;  Sung-Ho Lee  ;  Jeong Su Cho  ;  Jae Ik Lee  ;  Ho Choi  ;  Kwhanmien Kim  ;  Sanghoon Jheon 
 ANNALS OF THORACIC SURGERY, Vol.98(6) : 2005-2011, 2014 
Journal Title
Issue Date
Adolescent ; Adult ; Female ; Fibrin Tissue Adhesive ; Follow-Up Studies ; Humans ; Male ; Pleura/surgery* ; Pleurodesis/methods ; Pneumothorax/diagnostic imaging ; Pneumothorax/surgery* ; Prospective Studies ; Recurrence ; Surgical Wound Dehiscence/prevention & control* ; Suture Techniques* ; Thoracic Surgery, Video-Assisted/methods* ; Thoracoscopy/methods ; Tomography, X-Ray Computed ; Treatment Outcome ; Young Adult
BACKGROUND: Thoracoscopic wedge resection is generally accepted as a standard surgical procedure for primary spontaneous pneumothorax. Because of the relatively high recurrence rate after surgery, additional procedures such as mechanical pleurodesis or visceral pleural coverage are usually applied to minimize recurrence, although mechanical pleurodesis has some potential disadvantages. The aim of this study was to clarify whether an additional coverage procedure on the staple line after thoracoscopic bullectomy prevents postoperative recurrence compared with additional pleurodesis. METHODS: A total of 1,414 patients in 11 hospitals with primary spontaneous pneumothorax undergoing thoracoscopic bullectomy were enrolled. After bullectomy with staplers, patients were randomly assigned to either the coverage group (n = 757) or the pleurodesis group (n = 657). In the coverage group, the staple line was covered with absorbable cellulose mesh and fibrin glue. The pleurodesis group underwent additional mechanical abrasion on the parietal pleura. RESULTS: The coverage group and the pleurodesis group showed comparable surgical outcomes. After a median follow-up of 19.5 months, the postoperative 1-year recurrence rate was 9.5% in the coverage group and 10.7% in the pleurodesis group. The 1-year recurrence rate requiring intervention was 5.8% in the coverage group and 7.8% in the pleurodesis group. The coverage group showed better recovery from pain. CONCLUSIONS: In terms of postoperative recurrence rate, visceral pleural coverage after thoracoscopic bullectomy was not inferior to mechanical pleurodesis. Visceral pleural coverage may potentially replace mechanical pleurodesis, which has potential disadvantages such as disturbed normal pleural physiology.
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1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Paik, Hyo Chae(백효채) ORCID logo https://orcid.org/0000-0001-9309-8235
Lee, Sung Soo(이성수) ORCID logo https://orcid.org/0000-0001-8998-9510
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