547 309

Cited 0 times in

급성 Valproic acid 중독에서 L-carnitine과 체외 제거방법: 체계적 고찰

Other Titles
 L-carnitine vs Extracorporeal Elimination for Acute Valproic acid Intoxication: A Systematic Review 
Authors
 양병근  ;  구재은  ;  주영선  ;  유제성  ;  정성필  ;  이한식 
Citation
 Journal of the Korean Society of Clinical Toxicology (대한임상독성학회지), Vol.12(2) : 39-45, 2014 
Journal Title
 Journal of the Korean Society of Clinical Toxicology (대한임상독성학회지) 
ISSN
 1738-1320 
Issue Date
2014
Keywords
Valproic acid ; Poisoning ; Overdose ; Carnitine ; Renal dialysis
Abstract
Purpose: The purpose of this study is to review the evidence comparing the efficacy and safety between L-carnitine and extracorporeal elimination therapy in the management of acute valproic acid L-carnitine vs Extracorporeal Elimination for Acute Valproic acid Intoxication Methods: PubMed, Embase, Cochrane library, Web of Science, KoreaMed, KMbase, and KISS were searched, using the terms carnitine and valproic acid. All studies, regardless of design, reporting efficacy or safety endpoints were included. Reference citations from identified publications were reviewed. Both English and Korean languages were included. Two authors extracted primary data elements including poisoning severity, presenting features, clinical management, and outcomes. Results: Thirty two articles including 33 cases were identified. Poisoning severity was classified as 3 mild, 11 moderate, and 19 severe cases. Nine cases were treated with L-carnitine while 24 cases received extracorporeal therapy without L-carnitine. All patients except one expired patient treated with hemodialysis recovered clinically and no adverse effects were noted. A case report comparing two patients who ingested the same amount of valproic acid showed increased ICU stay (3 vs 11 days) in case of delayed extracorporeal therapy. Conclusion: Published evidence comparing L-carnitine with extracorporeal therapy is limited. Based on the available evidence, it is reasonable to consider L-carnitine for patients with acute valproic acid overdose. In case of severe poisoning, extracorporeal therapy would also be considered in the early phase of treatment.
Files in This Item:
T201405842.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
Yonsei Authors
Ku, Jae Eun(구재은)
You, Je Sung(유제성) ORCID logo https://orcid.org/0000-0002-2074-6745
Lee, Hahn Shick(이한식)
Chung, Sung Pil(정성필) ORCID logo https://orcid.org/0000-0002-3074-011X
Joo, Young Seon(주영선)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138953
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse