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Acute physical stress induces the alteration of the serotonin 1A receptor density in the hippocampus.

Authors
 Jae Yong Choi  ;  Sora Shin  ;  Minkyung Lee  ;  Tae Joo Jeon  ;  Youngbeom Seo  ;  Chul Hoon Kim  ;  Dong Goo Kim  ;  Chi Hoon Yi  ;  Kyochul Lee  ;  Tae Hyun Choi  ;  Jee Hae Kang  ;  Young Hoon Ryu 
Citation
 SYNAPSE, Vol.68(8) : 363-368, 2014 
Journal Title
 SYNAPSE 
ISSN
 0887-4476 
Issue Date
2014
MeSH
Acute Disease ; Animals ; Cerebellum/diagnostic imaging ; Cerebellum/physiopathology ; Depression/diagnostic imaging ; Depression/physiopathology* ; Disease Models, Animal ; Female ; Fluorine Radioisotopes ; Hippocampus/diagnostic imaging ; Hippocampus/physiopathology* ; Motor Activity/physiology ; Neuropsychological Tests ; Piperazines ; Positron-Emission Tomography ; Pyridines ; Radiopharmaceuticals ; Rats, Sprague-Dawley ; Receptor, Serotonin, 5-HT1A/metabolism* ; Stress, Physiological/physiology* ; Swimming/physiology ; Time Factors
Keywords
5-HT1A receptors ; PET ; [18F]Mefway ; acute stress
Abstract
Stress affects the serotonergic system, which is associated with depression. Previous research has showed that chronic stress causes the deactivation of the limbic system. However, the influence of the acute physical stress on the serotonergic system in vivo was primarily unclear. The purpose of this research is to elucidate the effects of the acute physical stress in vivo using PET. For quantification of the 5-HT1A receptors in the brain, we measured [(18)F]Mefway uptake in the two experiment groups (control and despair rats). The despair group was subjected to the external stressful situation (i.e., forced swimming) and total duration time of immobility, refers to the despair severity, and was analyzed. In the intercomparison experiment, the resulting PET images of [(18)F]Mefway in the despair rat displayed a significant reduction of radioactivity in the hippocampus (HP) compared with the control. The nondisplaceable binding potential (BPND ) refers to the ratio of the concentration of radioligand in the receptor-rich region (i.e., HP) to the concentration of that in the receptor-free region (i.e., cerebellum). The hippocampal uptake and the BPND in the despair group were respectively about 25 and 18% lower than those of the control group. The ratio of specific binding to nonspecific binding in the despair group was 18% lower than that of the control. In the intracomparison experiments, the BPND and immobility in the despair group showed a strong negative correlation. Taken together, the data illustrates that an acute physical stress induces the change in the serotonergic system that correlates with the behavioral despair.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/syn.21748/abstract
DOI
10.1002/syn.21748
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Goo(김동구)
Kim, Chul Hoon(김철훈) ORCID logo https://orcid.org/0000-0002-7360-429X
Shin, So Ra(신소라)
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Lee, Min Kyung(이민경)
Jeon, Tae Joo(전태주) ORCID logo https://orcid.org/0000-0002-7574-6734
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138885
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