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Analysis of rheumatoid factor according to various hepatitis B virus infectious statuses

 S T Choi  ;  H W Lee  ;  J S Song  ;  S K Lee  ;  Y B Park 
 Clinical and Experimental Rheumatology, Vol.32(2) : 168-173, 2014 
Journal Title
 Clinical and Experimental Rheumatology 
Issue Date
Adult ; Age Factors ; DNA, Viral/blood* ; Female ; Hepatitis B*/epidemiology ; Hepatitis B*/immunology ; Hepatitis B*/physiopathology ; Hepatitis B Antibodies/blood ; Hepatitis B Surface Antigens/blood ; Hepatitis B virus*/genetics ; Hepatitis B virus*/immunology ; Humans ; Male ; Middle Aged ; Patient Acuity ; Republic of Korea/epidemiology ; Rheumatoid Factor*/analysis ; Rheumatoid Factor*/blood ; Sex Factors ; Statistics as Topic ; Viral Load
OBJECTIVES: Rheumatoid factor (RF) can be seen in hepatitis B virus (HBV) infection. We investigated RF positive rates according to various HBV infectious statuses and vaccination, and the relationship between RF titers and serum HBV DNA levels. METHODS: We examined 13,670 individuals who visited the Severance Hospital in Seoul, Korea, for a routine health check-up, and obtained serum samples from all individuals. RESULTS: RF was positive in 3.5% of all subjects, and HBsAg was positive in 4.3%. HBsAg was positive in 21.7% of all RF positive subjects. RF was positive in 17.5% of the HBsAg positive group, while it was positive in 2.9% of the HBsAg negative group (p<0.001). The RF positive rate was increased in positive HBsAg, female sex, and older age. The RF positive rate was lower in those who had anti-HBs after HBV vaccination than in HBsAg positive subjects (2.7% vs. 17.5%, p<0.001). Among the RF positive patients, the RF titer in HBsAg positive patients were higher than that in HBsAg negative patients (159.7±217.1IU/mL vs. 83.0±179.2 IU/mL, p=0.001). The load of HBV DNA may be closely correlated with RF titer in patients with chronic hepatitis B (r=0.508, p=0.005). CONCLUSIONS: Persistent HBV infection is an important cause for the positive RF in HBV endemic areas. Hepatitis B viral load is associated with RF titer. HBV vaccination may reduce the risk of RF formation.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Yong Beom(박용범)
Lee, Soo Kon(이수곤)
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