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Efficacy, tolerability, and safety of oxybutynin chloride in pediatric neurogenic bladder with spinal dysraphism: a retrospective, multicenter, observational study.

 Jung Hoon Lee  ;  Kyoung Rok Kim  ;  Yong Seung Lee  ;  Sang Won Han  ;  Kun Suk Kim  ;  Sang Hoon Song  ;  Minki Baek  ;  Kwanjin Park 
 KOREAN JOURNAL OF UROLOGY, Vol.55(12) : 828-833, 2014 
Journal Title
Issue Date
Adolescent ; Child ; Child, Preschool ; Drug Evaluation/methods ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Mandelic Acids/adverse effects ; Mandelic Acids/therapeutic use* ; Muscarinic Antagonists/adverse effects ; Muscarinic Antagonists/therapeutic use* ; Retrospective Studies ; Spinal Dysraphism/complications* ; Treatment Outcome ; Urinary Bladder, Neurogenic/drug therapy* ; Urinary Bladder, Neurogenic/etiology ; Urinary Bladder, Neurogenic/physiopathology ; Urological Agents/adverse effects ; Urological Agents/therapeutic use*
Child ; Neurogenic urinary bladder ; Oxybutynin
PURPOSE: Anticholinergics are a key element in treating neurogenic detrusor overactivity, but only limited data are available in the pediatric population, thus limiting the application to children even for oxybutynin chloride (OC), a prototype drug. This retrospective study was designed to provide data regarding the efficacy, tolerability, and safety of OC in the pediatric population (0-15 years old) with spinal dysraphism (SD). MATERIALS AND METHODS: Records relevant to OC use for neurogenic bladder were gathered and scrutinized from four specialized clinics for pediatric urology. The primary efficacy outcomes were maximal cystometric capacity (MCC) and end filling pressure (EFP). Data on tolerability, compliance, and adverse events (AEs) were also analyzed. RESULTS: Of the 121 patient records analyzed, 41 patients (34%) received OC at less than 5 years of age. The range of prescribed doses varied from 3 to 24 mg/d. The median treatment duration was 19 months (range, 0.3-111 months). Significant improvement of both primary efficacy outcomes was noted following OC treatment. MCC increased about 8% even after adjustment for age-related increases in MCC. Likewise, mean EFP was reduced from 33 to 21 cm H2O. More than 80% of patients showed compliance above 70%, and approximately 50% of patients used OC for more than 1 year. No serious AEs were reported; constipation and facial flushing consisted of the major AEs. CONCLUSIONS: OC is safe and efficacious in treating pediatric neurogenic bladder associated with SD. The drug is also tolerable and the safety profile suggests that adjustment of dosage for age may not be strictly observed.
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1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Yong Seung(이용승) ORCID logo https://orcid.org/0000-0003-3778-9888
Han, Sang Won(한상원) ORCID logo https://orcid.org/0000-0003-0941-1300
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