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Efficacy, tolerability, and safety of oxybutynin chloride in pediatric neurogenic bladder with spinal dysraphism: a retrospective, multicenter, observational study.

DC FieldValueLanguage
dc.contributor.author이용승-
dc.contributor.author한상원-
dc.date.accessioned2015-12-28T11:07:08Z-
dc.date.available2015-12-28T11:07:08Z-
dc.date.issued2014-
dc.identifier.issn2005-6737-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/138732-
dc.description.abstractPURPOSE: Anticholinergics are a key element in treating neurogenic detrusor overactivity, but only limited data are available in the pediatric population, thus limiting the application to children even for oxybutynin chloride (OC), a prototype drug. This retrospective study was designed to provide data regarding the efficacy, tolerability, and safety of OC in the pediatric population (0-15 years old) with spinal dysraphism (SD). MATERIALS AND METHODS: Records relevant to OC use for neurogenic bladder were gathered and scrutinized from four specialized clinics for pediatric urology. The primary efficacy outcomes were maximal cystometric capacity (MCC) and end filling pressure (EFP). Data on tolerability, compliance, and adverse events (AEs) were also analyzed. RESULTS: Of the 121 patient records analyzed, 41 patients (34%) received OC at less than 5 years of age. The range of prescribed doses varied from 3 to 24 mg/d. The median treatment duration was 19 months (range, 0.3-111 months). Significant improvement of both primary efficacy outcomes was noted following OC treatment. MCC increased about 8% even after adjustment for age-related increases in MCC. Likewise, mean EFP was reduced from 33 to 21 cm H2O. More than 80% of patients showed compliance above 70%, and approximately 50% of patients used OC for more than 1 year. No serious AEs were reported; constipation and facial flushing consisted of the major AEs. CONCLUSIONS: OC is safe and efficacious in treating pediatric neurogenic bladder associated with SD. The drug is also tolerable and the safety profile suggests that adjustment of dosage for age may not be strictly observed.-
dc.description.statementOfResponsibilityopen-
dc.format.extent828~833-
dc.relation.isPartOfKOREAN JOURNAL OF UROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHDrug Evaluation/methods-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInfant-
dc.subject.MESHInfant, Newborn-
dc.subject.MESHMale-
dc.subject.MESHMandelic Acids/adverse effects-
dc.subject.MESHMandelic Acids/therapeutic use*-
dc.subject.MESHMuscarinic Antagonists/adverse effects-
dc.subject.MESHMuscarinic Antagonists/therapeutic use*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSpinal Dysraphism/complications*-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHUrinary Bladder, Neurogenic/drug therapy*-
dc.subject.MESHUrinary Bladder, Neurogenic/etiology-
dc.subject.MESHUrinary Bladder, Neurogenic/physiopathology-
dc.subject.MESHUrological Agents/adverse effects-
dc.subject.MESHUrological Agents/therapeutic use*-
dc.titleEfficacy, tolerability, and safety of oxybutynin chloride in pediatric neurogenic bladder with spinal dysraphism: a retrospective, multicenter, observational study.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Urology (비뇨기과학)-
dc.contributor.googleauthorJung Hoon Lee-
dc.contributor.googleauthorKyoung Rok Kim-
dc.contributor.googleauthorYong Seung Lee-
dc.contributor.googleauthorSang Won Han-
dc.contributor.googleauthorKun Suk Kim-
dc.contributor.googleauthorSang Hoon Song-
dc.contributor.googleauthorMinki Baek-
dc.contributor.googleauthorKwanjin Park-
dc.identifier.doi10.4111/kju.2014.55.12.828-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04285-
dc.contributor.localIdA02980-
dc.relation.journalcodeJ02134-
dc.identifier.eissn2005-6745-
dc.identifier.pmid25512818-
dc.subject.keywordChild-
dc.subject.keywordNeurogenic urinary bladder-
dc.subject.keywordOxybutynin-
dc.contributor.alternativeNameLee, Yong Seung-
dc.contributor.alternativeNameHan, Sang Won-
dc.contributor.affiliatedAuthorHan, Sang Won-
dc.contributor.affiliatedAuthorLee, Yong Seung-
dc.citation.volume55-
dc.citation.number12-
dc.citation.startPage828-
dc.citation.endPage833-
dc.identifier.bibliographicCitationKOREAN JOURNAL OF UROLOGY, Vol.55(12) : 828-833, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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