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Human bocavirus isolated from children with acute respiratory tract infections in Korea, 2010-2011.

 Jong Gyun Ahn  ;  Seong Yeol Choi  ;  Dong Soo Kim  ;  Ki Hwan Kim 
 JOURNAL OF MEDICAL VIROLOGY, Vol.86(12) : 2011-2018, 2014 
Journal Title
Issue Date
Child ; Child, Preschool ; Cluster Analysis ; Coinfection/epidemiology ; Coinfection/virology ; DNA, Viral/chemistry ; DNA, Viral/genetics ; Female ; Genetic Variation ; Genotype ; Human bocavirus/classification ; Human bocavirus/genetics ; Human bocavirus/isolation & purification* ; Humans ; Infant ; Male ; Molecular Sequence Data ; Multiplex Polymerase Chain Reaction ; Nasopharynx/virology ; Parvoviridae Infections/epidemiology* ; Parvoviridae Infections/pathology ; Parvoviridae Infections/virology* ; Phylogeny ; Prevalence ; Republic of Korea/epidemiology ; Respiratory Tract Infections/epidemiology* ; Respiratory Tract Infections/pathology ; Respiratory Tract Infections/virology* ; Seasons ; Sequence Analysis, DNA ; Sequence Homology ; Viral Structural Proteins/genetics
acute respiratory infections ; human bocavirus ; phylogenetic analysis
Human bocavirus (HBoV) was first recognized in respiratory samples in 2005. The clinical importance of HBoV infection remains unclear. This report describes the clinical features and molecular phylogeny of HBoV isolates in children with acute respiratory infections. Nasopharyngeal aspirates were obtained from 1,528 children with acute respiratory infections between 2010 and 2011. Respiratory samples were screened for HBoV by multiplex PCR. A phylogenetic analysis of the HBoV VP1/VP2 gene was also undertaken. HBoV was detected in 187 (12.2%) of the 1,528 patients with a peak incidence of infection observed in patients aged 12-24 months. Coinfection with other respiratory viruses was observed in 107 (57.2%) of the HBoV-positive children. The peak of HBoV activity occurred during the month of June in both 2010 and 2011. A higher previous history of wheezing (P = 0.016), a higher frequency of chest retraction (P < 0.001) and wheezing (P = 0.022), a higher respiratory symptom score (P = 0.002), and a longer duration of hospital stay (P = 0.021) were observed in HBoV-positive children compared with the HBoV-negative group. Phylogenetic analysis showed all 187 HBoV-positive isolates were identified as HBoV 1, indicating minimal sequence variations among the isolates. A single lineage of HBoV 1 was found to have circulated in children with acute respiratory infections between 2010 and 2011 and was associated with several clinical characteristics including age, seasonality, and clinical severity with retraction, wheezing, and longer hospitalization. The clinical relevance of the minimal sequence variations of HBoV remains to be determined.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Hwan(김기환)
Kim, Dong Soo(김동수)
Ahn, Jong Gyun(안종균) ORCID logo https://orcid.org/0000-0001-5748-0015
Choi, Seong Yeol(최성열)
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