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Human bocavirus isolated from children with acute respiratory tract infections in Korea, 2010-2011.

DC Field Value Language
dc.contributor.author김기환-
dc.contributor.author김동수-
dc.contributor.author안종균-
dc.contributor.author최성열-
dc.date.accessioned2015-12-28T11:01:28Z-
dc.date.available2015-12-28T11:01:28Z-
dc.date.issued2014-
dc.identifier.issn0146-6615-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/138529-
dc.description.abstractHuman bocavirus (HBoV) was first recognized in respiratory samples in 2005. The clinical importance of HBoV infection remains unclear. This report describes the clinical features and molecular phylogeny of HBoV isolates in children with acute respiratory infections. Nasopharyngeal aspirates were obtained from 1,528 children with acute respiratory infections between 2010 and 2011. Respiratory samples were screened for HBoV by multiplex PCR. A phylogenetic analysis of the HBoV VP1/VP2 gene was also undertaken. HBoV was detected in 187 (12.2%) of the 1,528 patients with a peak incidence of infection observed in patients aged 12-24 months. Coinfection with other respiratory viruses was observed in 107 (57.2%) of the HBoV-positive children. The peak of HBoV activity occurred during the month of June in both 2010 and 2011. A higher previous history of wheezing (P = 0.016), a higher frequency of chest retraction (P < 0.001) and wheezing (P = 0.022), a higher respiratory symptom score (P = 0.002), and a longer duration of hospital stay (P = 0.021) were observed in HBoV-positive children compared with the HBoV-negative group. Phylogenetic analysis showed all 187 HBoV-positive isolates were identified as HBoV 1, indicating minimal sequence variations among the isolates. A single lineage of HBoV 1 was found to have circulated in children with acute respiratory infections between 2010 and 2011 and was associated with several clinical characteristics including age, seasonality, and clinical severity with retraction, wheezing, and longer hospitalization. The clinical relevance of the minimal sequence variations of HBoV remains to be determined.-
dc.description.statementOfResponsibilityopen-
dc.format.extent2011~2018-
dc.relation.isPartOfJOURNAL OF MEDICAL VIROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHCluster Analysis-
dc.subject.MESHCoinfection/epidemiology-
dc.subject.MESHCoinfection/virology-
dc.subject.MESHDNA, Viral/chemistry-
dc.subject.MESHDNA, Viral/genetics-
dc.subject.MESHFemale-
dc.subject.MESHGenetic Variation-
dc.subject.MESHGenotype-
dc.subject.MESHHuman bocavirus/classification-
dc.subject.MESHHuman bocavirus/genetics-
dc.subject.MESHHuman bocavirus/isolation & purification*-
dc.subject.MESHHumans-
dc.subject.MESHInfant-
dc.subject.MESHMale-
dc.subject.MESHMolecular Sequence Data-
dc.subject.MESHMultiplex Polymerase Chain Reaction-
dc.subject.MESHNasopharynx/virology-
dc.subject.MESHParvoviridae Infections/epidemiology*-
dc.subject.MESHParvoviridae Infections/pathology-
dc.subject.MESHParvoviridae Infections/virology*-
dc.subject.MESHPhylogeny-
dc.subject.MESHPrevalence-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRespiratory Tract Infections/epidemiology*-
dc.subject.MESHRespiratory Tract Infections/pathology-
dc.subject.MESHRespiratory Tract Infections/virology*-
dc.subject.MESHSeasons-
dc.subject.MESHSequence Analysis, DNA-
dc.subject.MESHSequence Homology-
dc.subject.MESHViral Structural Proteins/genetics-
dc.titleHuman bocavirus isolated from children with acute respiratory tract infections in Korea, 2010-2011.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorJong Gyun Ahn-
dc.contributor.googleauthorSeong Yeol Choi-
dc.contributor.googleauthorDong Soo Kim-
dc.contributor.googleauthorKi Hwan Kim-
dc.identifier.doi10.1002/jmv.23880-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00344-
dc.contributor.localIdA02261-
dc.contributor.localIdA04078-
dc.contributor.localIdA00405-
dc.relation.journalcodeJ01587-
dc.identifier.eissn1096-9071-
dc.identifier.pmid24390980-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/jmv.23880/abstract-
dc.subject.keywordacute respiratory infections-
dc.subject.keywordhuman bocavirus-
dc.subject.keywordphylogenetic analysis-
dc.contributor.alternativeNameKim, Ki Hwan-
dc.contributor.alternativeNameKim, Dong Soo-
dc.contributor.alternativeNameAhn, Jong Gyun-
dc.contributor.alternativeNameChoi, Seong Yeol-
dc.contributor.affiliatedAuthorKim, Ki Hwan-
dc.contributor.affiliatedAuthorAhn, Jong Gyun-
dc.contributor.affiliatedAuthorChoi, Seong Yeol-
dc.contributor.affiliatedAuthorKim, Dong Soo-
dc.rights.accessRightsfree-
dc.citation.volume86-
dc.citation.number12-
dc.citation.startPage2011-
dc.citation.endPage2018-
dc.identifier.bibliographicCitationJOURNAL OF MEDICAL VIROLOGY, Vol.86(12) : 2011-2018, 2014-
dc.identifier.rimsid38362-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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