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Efficacy and safety of micafungin for the prophylaxis of invasive fungal infection during neutropenia in children and adolescents undergoing allogeneic hematopoietic SCT

 H J Park  ;  M Park  ;  M Han  ;  B H Nam  ;  K N Koh  ;  H J Im  ;  J W Lee  ;  N-G Chung  ;  B Cho  ;  H-K Kim  ;  K H Yoo  ;  H H Koo  ;  H J Kang  ;  H Y Shin  ;  H S Ahn  ;  Y T Lim  ;  H Kook  ;  C J Lyu  ;  J O Hah  ;  J E Park  ;  Y J Lim  ;  J J Seo 
 BONE MARROW TRANSPLANTATION, Vol.49(9) : 1212-1216, 2014 
Journal Title
Issue Date
Adolescent ; Adult ; Antifungal Agents/adverse effects ; Antifungal Agents/therapeutic use* ; Child ; Child, Preschool ; Echinocandins/adverse effects ; Echinocandins/therapeutic use* ; Female ; Hematopoietic Stem Cell Transplantation/methods* ; Humans ; Infant ; Infant, Newborn ; Lipopeptides/adverse effects ; Lipopeptides/therapeutic use* ; Male ; Neutropenia/microbiology* ; Prospective Studies ; Transplantation Conditioning/methods ; Treatment Outcome ; Young Adult
The objective of this study was to evaluate the efficacy and safety of micafungin for the prevention of invasive fungal infection (IFI) during the neutropenic phase of allogeneic hematopoietic SCT (allo-HSCT) in children and adolescents. This was a prospective, multicenter, open-label, single-arm study. Micafungin was administered i.v. at a dose of 1 mg/kg/day (max 50 mg) from the beginning of conditioning until neutrophil engraftment. Treatment success was defined as the absence of proven, probable, possible or suspected IFI through to 4 weeks after therapy. From April 2010 to December 2011, 155 patients were enrolled from 11 institutions in Korea, and 147 patients were analyzed. Of the 147 patients, 121 (82.3%) completed the protocol without premature interruption. Of the 132 patients in whom micafungin efficacy could be evaluated, treatment success was achieved in 119 patients (90.2%). There was no proven fungal infection in any patient. The number of patients with probable, possible and suspected IFI was two, two and nine, respectively. Thirty-five patients (23.8%) experienced 109 adverse events (AEs) possibly related to micafungin. No patients experienced grade IV AEs. Two patients (1.4%) discontinued micafungin administration due to adverse effects. None of the deaths were related to the study drug.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Lyu, Chuhl Joo(유철주) ORCID logo https://orcid.org/0000-0001-7124-7818
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