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Efficacy and safety of micafungin for the prophylaxis of invasive fungal infection during neutropenia in children and adolescents undergoing allogeneic hematopoietic SCT

DC Field Value Language
dc.contributor.author유철주-
dc.date.accessioned2015-12-28T11:01:16Z-
dc.date.available2015-12-28T11:01:16Z-
dc.date.issued2014-
dc.identifier.issn0268-3369-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/138522-
dc.description.abstractThe objective of this study was to evaluate the efficacy and safety of micafungin for the prevention of invasive fungal infection (IFI) during the neutropenic phase of allogeneic hematopoietic SCT (allo-HSCT) in children and adolescents. This was a prospective, multicenter, open-label, single-arm study. Micafungin was administered i.v. at a dose of 1 mg/kg/day (max 50 mg) from the beginning of conditioning until neutrophil engraftment. Treatment success was defined as the absence of proven, probable, possible or suspected IFI through to 4 weeks after therapy. From April 2010 to December 2011, 155 patients were enrolled from 11 institutions in Korea, and 147 patients were analyzed. Of the 147 patients, 121 (82.3%) completed the protocol without premature interruption. Of the 132 patients in whom micafungin efficacy could be evaluated, treatment success was achieved in 119 patients (90.2%). There was no proven fungal infection in any patient. The number of patients with probable, possible and suspected IFI was two, two and nine, respectively. Thirty-five patients (23.8%) experienced 109 adverse events (AEs) possibly related to micafungin. No patients experienced grade IV AEs. Two patients (1.4%) discontinued micafungin administration due to adverse effects. None of the deaths were related to the study drug.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1212~1216-
dc.relation.isPartOfBONE MARROW TRANSPLANTATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAntifungal Agents/adverse effects-
dc.subject.MESHAntifungal Agents/therapeutic use*-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHEchinocandins/adverse effects-
dc.subject.MESHEchinocandins/therapeutic use*-
dc.subject.MESHFemale-
dc.subject.MESHHematopoietic Stem Cell Transplantation/methods*-
dc.subject.MESHHumans-
dc.subject.MESHInfant-
dc.subject.MESHInfant, Newborn-
dc.subject.MESHLipopeptides/adverse effects-
dc.subject.MESHLipopeptides/therapeutic use*-
dc.subject.MESHMale-
dc.subject.MESHNeutropenia/microbiology*-
dc.subject.MESHProspective Studies-
dc.subject.MESHTransplantation Conditioning/methods-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.titleEfficacy and safety of micafungin for the prophylaxis of invasive fungal infection during neutropenia in children and adolescents undergoing allogeneic hematopoietic SCT-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorH J Park-
dc.contributor.googleauthorM Park-
dc.contributor.googleauthorM Han-
dc.contributor.googleauthorB H Nam-
dc.contributor.googleauthorK N Koh-
dc.contributor.googleauthorH J Im-
dc.contributor.googleauthorJ W Lee-
dc.contributor.googleauthorN-G Chung-
dc.contributor.googleauthorB Cho-
dc.contributor.googleauthorH-K Kim-
dc.contributor.googleauthorK H Yoo-
dc.contributor.googleauthorH H Koo-
dc.contributor.googleauthorH J Kang-
dc.contributor.googleauthorH Y Shin-
dc.contributor.googleauthorH S Ahn-
dc.contributor.googleauthorY T Lim-
dc.contributor.googleauthorH Kook-
dc.contributor.googleauthorC J Lyu-
dc.contributor.googleauthorJ O Hah-
dc.contributor.googleauthorJ E Park-
dc.contributor.googleauthorY J Lim-
dc.contributor.googleauthorJ J Seo-
dc.identifier.doi10.1038/bmt.2014.136-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02524-
dc.relation.journalcodeJ00383-
dc.identifier.eissn1476-5365-
dc.identifier.pmid25000455-
dc.identifier.urlhttp://www.nature.com/bmt/journal/v49/n9/full/bmt2014136a.html-
dc.contributor.alternativeNameLyu, Chuhl Joo-
dc.contributor.affiliatedAuthorLyu, Chuhl Joo-
dc.rights.accessRightsfree-
dc.citation.volume49-
dc.citation.number9-
dc.citation.startPage1212-
dc.citation.endPage1216-
dc.identifier.bibliographicCitationBONE MARROW TRANSPLANTATION, Vol.49(9) : 1212-1216, 2014-
dc.identifier.rimsid45368-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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