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소아 천식 환아의 호기농축시료에서 염증매개물질 측정의 의의

Other Titles
 Increased inflammatory mediator in exhaled breath condensate from asthmatic children 
Authors
 한윤기  ;  박준영  ;  김미나  ;  김윤희  ;  박현빈  ;  김민정  ;  이경은  ;  이희선  ;  허원일  ;  홍정연  ;  김경원  ;  손명현  ;  김규언 
Citation
 ALLERGY ASTHMA & RESPIRATORY DISEASE, Vol.2(5) : 332-336, 2014 
Journal Title
 ALLERGY ASTHMA & RESPIRATORY DISEASE 
ISSN
 2288-0402 
Issue Date
2014
MeSH
Asthma/metabolism* ; Biomarkers/analysis ; Breath Tests/methods* ; Child ; Chromatography, Liquid* ; Cross-Sectional Studies ; Exhalation* ; Female ; Humans ; Leukotriene B4/analysis* ; Male ; Mass Spectrometry* ; Nitric Oxide/analysis*
Keywords
Asthma ; Exhaled breath condensate ; Leukotriene B4 ; Eosinophil cationic protein
Abstract
Purpose: There has recently been increasing interest in the use of exhaled breath condensate (EBC) as a simple noninvasive means for understanding the physiology of asthma. The aim of this study was to evaluate the levels of leukotriene B4 (LTB4) and eosinophil cationic protein (ECP) in the EBC of asthmatic children. Methods: We measured LTB4 and ECP levels in EBC from children aged 6.14 years, including healthy children (n=25) and asthmatic children (n=25). We also measured serum LTB4 and serum ECP. Pulmonary function tests and methacholine challenge tests were performed on all subjects. Results: Exhaled LTB4 levels were increased significantly in patients with asthma compared to normal subjects (7.1±3.7 pg/mL vs. 2.2±1.7 pg/mL, P<0.05). Serum LTB4 levels were not significantly different in patients with asthma compared to normal subjects (674.7±484.1 pg/mL vs. 487.1±272.0 pg/mL, P=0.156,) and no significant correlations were found between exhaled and serum LTB4 concentrations in children with asthma (r=0.052, P=0.758). Exhaled ECP levels were not significantly different in patients with asthma compared to normal subjects (P=0.419). Serum ECP levels were significantly increased in patients with asthma compared to normal subjects (44.37±32.14 μg/L vs. 16.40±13.23 μg/L, P=0.001). Conclusion: We found significantly elevated LTB4 levels in the EBC of asthmatic children. Our results suggest that EBC may be one of the supportive tools to measure airway inflammation in children with asthma.
Files in This Item:
T201404689.pdf Download
DOI
10.4168/aard.2014.2.5.332
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Kyu Earn(김규언)
Kim, Mina(김미나) ORCID logo https://orcid.org/0000-0002-1675-0688
Kim, Min Jung(김민정) ORCID logo https://orcid.org/0000-0002-5634-9709
Kim, Yoon Hee(김윤희) ORCID logo https://orcid.org/0000-0002-2149-8501
Park, Jun Young(박준영)
Park, Hyun Bin(박현빈)
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
Lee, Kyung Eun(이경은)
Lee, Hee Seon(이희선)
Han, Yoon Ki(한윤기)
Heo, Won Il(허원일)
Hong, Jung Yeon(홍정연) ORCID logo https://orcid.org/0000-0003-0406-9956
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138505
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