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Phosphorylation of hypothalamic AMPK on serine(485/491) related to sustained weight loss by alpha-lipoic acid in mice treated with olanzapine.

DC FieldValueLanguage
dc.contributor.author김현정-
dc.contributor.author남궁기-
dc.contributor.author박민선-
dc.contributor.author박진영-
dc.contributor.author이병인-
dc.contributor.author이수경-
dc.contributor.author정지현-
dc.contributor.author조현상-
dc.contributor.author김어수-
dc.date.accessioned2015-12-28T10:58:25Z-
dc.date.available2015-12-28T10:58:25Z-
dc.date.issued2014-
dc.identifier.issn0033-3158-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/138421-
dc.description.abstractRATIONALE: Alpha-lipoic acid (ALA) was shown to suppress atypical antipsychotic drug (AAPD)-induced weight gain. However, its mode of action has remained unidentified. OBJECTIVE: We aimed to identify mechanisms underlying anti-obesity effects of ALA in mice treated with olanzapine. METHODS: We compared body weight and food intake among vehicle-, olanzapine-, and olanzapine plus ALA-treated mice, and measured hypothalamic AMP-activated protein kinase (AMPK) activity by detecting levels of Thr(172) and Ser(485/491) phosphorylation, which indicate activation and inhibition of AMPK, respectively. RESULTS: Body weights were increased by olanzapine in parallel with increased levels of Thr(172) phosphorylation of hypothalamic AMPK. Initially increased rate of weight gain was diminished as Thr(172) phosphorylation levels were decreased to control levels after 10 days of olanzapine treatment. ALA successfully not only prevented olanzapine-induced weight gain but also induced additional weight loss even relative to control levels throughout the treatment period. During the initial stage, ALA's action was indicated by both suppression of olanzapine-induced Thr(172) phosphorylation and an increase in Ser(485/491) phosphorylation levels. However, in the later stage when no more increases in Thr(172) phosphorylation and weight gain by olanzapine were observed, ALA's action was only indicated by increased levels of Ser(485/491) phosphorylation. CONCLUSIONS: Our data suggest that anti-obesity effects of ALA may be related to modulation of both Ser(485/491) phosphorylation and Thr(172) phosphorylation of hypothalamic AMPK, while olanzapine-induced weight gain may be only associated with increase in Thr(172) phosphorylation. This might be an important mechanistic clue for the future development of anti-obesity drugs beyond control of AAPD-induced weight gain.-
dc.description.statementOfResponsibilityopen-
dc.format.extent4059~4069-
dc.relation.isPartOfPSYCHOPHARMACOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAMP-Activated Protein Kinases/metabolism*-
dc.subject.MESHAnimals-
dc.subject.MESHAnti-Obesity Agents/pharmacology-
dc.subject.MESHAntipsychotic Agents/pharmacology*-
dc.subject.MESHBenzodiazepines/pharmacology*-
dc.subject.MESHBody Weight/drug effects-
dc.subject.MESHEating/drug effects-
dc.subject.MESHFemale-
dc.subject.MESHHypothalamus/drug effects-
dc.subject.MESHHypothalamus/metabolism*-
dc.subject.MESHMice-
dc.subject.MESHObesity/drug therapy-
dc.subject.MESHObesity/metabolism-
dc.subject.MESHPhosphorylation/drug effects-
dc.subject.MESHSerine/pharmacology-
dc.subject.MESHThioctic Acid/pharmacology*-
dc.subject.MESHThioctic Acid/therapeutic use-
dc.subject.MESHWeight Gain/drug effects*-
dc.subject.MESHWeight Loss/drug effects*-
dc.titlePhosphorylation of hypothalamic AMPK on serine(485/491) related to sustained weight loss by alpha-lipoic acid in mice treated with olanzapine.-
dc.typeArticle-
dc.contributor.collegeResearcher Institutes (부설 연구소)-
dc.contributor.departmentInstitute of Behavioral Sciences in Medicine (의학행동과학연구소)-
dc.contributor.googleauthorHyunjeong Kim-
dc.contributor.googleauthorMinsun Park-
dc.contributor.googleauthorSu Kyoung Lee-
dc.contributor.googleauthorJihyeon Jeong-
dc.contributor.googleauthorKee Namkoong-
dc.contributor.googleauthorHyun Sang Cho-
dc.contributor.googleauthorJin Young Park-
dc.contributor.googleauthorByung In Lee-
dc.contributor.googleauthorEosu Kim-
dc.identifier.doi10.1007/s00213-014-3540-3-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01240-
dc.contributor.localIdA01466-
dc.contributor.localIdA02797-
dc.contributor.localIdA02888-
dc.contributor.localIdA03738-
dc.contributor.localIdA03928-
dc.contributor.localIdA00686-
dc.contributor.localIdA01701-
dc.contributor.localIdA01130-
dc.relation.journalcodeJ02575-
dc.identifier.eissn1432-2072-
dc.identifier.pmid24733236-
dc.identifier.urlhttp://link.springer.com/article/10.1007/s00213-014-3540-3-
dc.subject.keywordOlanzapine-
dc.subject.keywordAlpha-lipoic acid-
dc.subject.keywordAMPK-
dc.subject.keywordAntipsychotics-
dc.subject.keywordObesity-
dc.subject.keywordLeptin-
dc.subject.keywordGhrelin-
dc.contributor.alternativeNameKim, Hyun Jeong-
dc.contributor.alternativeNameNamkoong, Kee-
dc.contributor.alternativeNamePark, Min Sun-
dc.contributor.alternativeNamePark, Jin Young-
dc.contributor.alternativeNameLee, Byung In-
dc.contributor.alternativeNameLee, Su Kyoung-
dc.contributor.alternativeNameJeong, Jihyeon-
dc.contributor.alternativeNameCho, Hyun Sang-
dc.contributor.alternativeNameKim, Eo Su-
dc.contributor.affiliatedAuthorNamkoong, Kee-
dc.contributor.affiliatedAuthorPark, Min Sun-
dc.contributor.affiliatedAuthorLee, Byung In-
dc.contributor.affiliatedAuthorLee, Su Kyoung-
dc.contributor.affiliatedAuthorJeong, Jihyeon-
dc.contributor.affiliatedAuthorCho, Hyun Sang-
dc.contributor.affiliatedAuthorKim, Eo Su-
dc.contributor.affiliatedAuthorPark, Jin Young-
dc.contributor.affiliatedAuthorKim, Hyun Jeong-
dc.rights.accessRightsfree-
dc.citation.volume231-
dc.citation.number20-
dc.citation.startPage4059-
dc.citation.endPage4069-
dc.identifier.bibliographicCitationPSYCHOPHARMACOLOGY, Vol.231(20) : 4059-4069, 2014-
Appears in Collections:
5. Research Institutes (연구소) > Institute of Behavioral Sciences in Medicine (의학행동과학연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers

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