Cited 8 times in
Phosphorylation of hypothalamic AMPK on serine(485/491) related to sustained weight loss by alpha-lipoic acid in mice treated with olanzapine.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김현정 | - |
dc.contributor.author | 남궁기 | - |
dc.contributor.author | 박민선 | - |
dc.contributor.author | 박진영 | - |
dc.contributor.author | 이병인 | - |
dc.contributor.author | 이수경 | - |
dc.contributor.author | 정지현 | - |
dc.contributor.author | 조현상 | - |
dc.contributor.author | 김어수 | - |
dc.date.accessioned | 2015-12-28T10:58:25Z | - |
dc.date.available | 2015-12-28T10:58:25Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0033-3158 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/138421 | - |
dc.description.abstract | RATIONALE: Alpha-lipoic acid (ALA) was shown to suppress atypical antipsychotic drug (AAPD)-induced weight gain. However, its mode of action has remained unidentified. OBJECTIVE: We aimed to identify mechanisms underlying anti-obesity effects of ALA in mice treated with olanzapine. METHODS: We compared body weight and food intake among vehicle-, olanzapine-, and olanzapine plus ALA-treated mice, and measured hypothalamic AMP-activated protein kinase (AMPK) activity by detecting levels of Thr(172) and Ser(485/491) phosphorylation, which indicate activation and inhibition of AMPK, respectively. RESULTS: Body weights were increased by olanzapine in parallel with increased levels of Thr(172) phosphorylation of hypothalamic AMPK. Initially increased rate of weight gain was diminished as Thr(172) phosphorylation levels were decreased to control levels after 10 days of olanzapine treatment. ALA successfully not only prevented olanzapine-induced weight gain but also induced additional weight loss even relative to control levels throughout the treatment period. During the initial stage, ALA's action was indicated by both suppression of olanzapine-induced Thr(172) phosphorylation and an increase in Ser(485/491) phosphorylation levels. However, in the later stage when no more increases in Thr(172) phosphorylation and weight gain by olanzapine were observed, ALA's action was only indicated by increased levels of Ser(485/491) phosphorylation. CONCLUSIONS: Our data suggest that anti-obesity effects of ALA may be related to modulation of both Ser(485/491) phosphorylation and Thr(172) phosphorylation of hypothalamic AMPK, while olanzapine-induced weight gain may be only associated with increase in Thr(172) phosphorylation. This might be an important mechanistic clue for the future development of anti-obesity drugs beyond control of AAPD-induced weight gain. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 4059~4069 | - |
dc.relation.isPartOf | PSYCHOPHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | AMP-Activated Protein Kinases/metabolism* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Anti-Obesity Agents/pharmacology | - |
dc.subject.MESH | Antipsychotic Agents/pharmacology* | - |
dc.subject.MESH | Benzodiazepines/pharmacology* | - |
dc.subject.MESH | Body Weight/drug effects | - |
dc.subject.MESH | Eating/drug effects | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hypothalamus/drug effects | - |
dc.subject.MESH | Hypothalamus/metabolism* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Obesity/drug therapy | - |
dc.subject.MESH | Obesity/metabolism | - |
dc.subject.MESH | Phosphorylation/drug effects | - |
dc.subject.MESH | Serine/pharmacology | - |
dc.subject.MESH | Thioctic Acid/pharmacology* | - |
dc.subject.MESH | Thioctic Acid/therapeutic use | - |
dc.subject.MESH | Weight Gain/drug effects* | - |
dc.subject.MESH | Weight Loss/drug effects* | - |
dc.title | Phosphorylation of hypothalamic AMPK on serine(485/491) related to sustained weight loss by alpha-lipoic acid in mice treated with olanzapine. | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Institute of Behavioral Sciences in Medicine (의학행동과학연구소) | - |
dc.contributor.googleauthor | Hyunjeong Kim | - |
dc.contributor.googleauthor | Minsun Park | - |
dc.contributor.googleauthor | Su Kyoung Lee | - |
dc.contributor.googleauthor | Jihyeon Jeong | - |
dc.contributor.googleauthor | Kee Namkoong | - |
dc.contributor.googleauthor | Hyun Sang Cho | - |
dc.contributor.googleauthor | Jin Young Park | - |
dc.contributor.googleauthor | Byung In Lee | - |
dc.contributor.googleauthor | Eosu Kim | - |
dc.identifier.doi | 10.1007/s00213-014-3540-3 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01240 | - |
dc.contributor.localId | A01466 | - |
dc.contributor.localId | A02797 | - |
dc.contributor.localId | A02888 | - |
dc.contributor.localId | A03738 | - |
dc.contributor.localId | A03928 | - |
dc.contributor.localId | A00686 | - |
dc.contributor.localId | A01701 | - |
dc.contributor.localId | A01130 | - |
dc.relation.journalcode | J02575 | - |
dc.identifier.eissn | 1432-2072 | - |
dc.identifier.pmid | 24733236 | - |
dc.identifier.url | http://link.springer.com/article/10.1007/s00213-014-3540-3 | - |
dc.subject.keyword | Olanzapine | - |
dc.subject.keyword | Alpha-lipoic acid | - |
dc.subject.keyword | AMPK | - |
dc.subject.keyword | Antipsychotics | - |
dc.subject.keyword | Obesity | - |
dc.subject.keyword | Leptin | - |
dc.subject.keyword | Ghrelin | - |
dc.contributor.alternativeName | Kim, Hyun Jeong | - |
dc.contributor.alternativeName | Namkoong, Kee | - |
dc.contributor.alternativeName | Park, Min Sun | - |
dc.contributor.alternativeName | Park, Jin Young | - |
dc.contributor.alternativeName | Lee, Byung In | - |
dc.contributor.alternativeName | Lee, Su Kyoung | - |
dc.contributor.alternativeName | Jeong, Jihyeon | - |
dc.contributor.alternativeName | Cho, Hyun Sang | - |
dc.contributor.alternativeName | Kim, Eo Su | - |
dc.contributor.affiliatedAuthor | Namkoong, Kee | - |
dc.contributor.affiliatedAuthor | Park, Min Sun | - |
dc.contributor.affiliatedAuthor | Lee, Byung In | - |
dc.contributor.affiliatedAuthor | Lee, Su Kyoung | - |
dc.contributor.affiliatedAuthor | Jeong, Jihyeon | - |
dc.contributor.affiliatedAuthor | Cho, Hyun Sang | - |
dc.contributor.affiliatedAuthor | Kim, Eo Su | - |
dc.contributor.affiliatedAuthor | Park, Jin Young | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Jeong | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 231 | - |
dc.citation.number | 20 | - |
dc.citation.startPage | 4059 | - |
dc.citation.endPage | 4069 | - |
dc.identifier.bibliographicCitation | PSYCHOPHARMACOLOGY, Vol.231(20) : 4059-4069, 2014 | - |
dc.identifier.rimsid | 49165 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.