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생분해성 마이크로니들 패치(Biodegradable Microneedle Patch)를 이용한 눈가 주름의 개선에 관한 연구

Other Titles
 Efficacy of Biodegradable Microneedle Patches on Periorbital Wrinkles 
Authors
 박지훈  ;  서지명  ;  신정우  ;  정도현  ;  김정동  ;  이광훈 
Citation
 Korean Journal of Dermatology (대한피부과학회지), Vol.52(9) : 597-607, 2014 
Journal Title
Korean Journal of Dermatology(대한피부과학회지)
ISSN
 0494-4739 
Issue Date
2014
Keywords
Epidermal growth factor ; Hyaluronic acid ; Microneedle patch ; Periorbital wrinkles
Abstract
BACKGROUND: Biodegradable microneedle technology is a recently developed method to deliver medical and pharmaceutical medications into the skin, and is expected to yield better treatment results than topical application methods.
OBJECTIVE: To evaluate the efficacy of hyaluronic acid (HA)-based microneedle patches and epidermal growth factor (EGF)-containing microneedle patches on periorbital wrinkle improvement.
METHODS: A 20-week randomized, double-blind study was performed. Twenty-five Korean patients with periorbital wrinkles and a wrinkle severity rating scale (WSRS) score above 2 were enrolled into the study. The patients completed the study using the two different types of patches on each side of the designated periorbital wrinkles area every other day for 8 weeks. Patients were requested for an additional 12-week follow up. Wrinkle improvements were assessed by WSRS score, subjective patient satisfaction score, and imaging analysis using the visiometer, corneometer, cutometer, and mexameter, respectively (Courage&Khazaka, Cologne, Germany).
RESULTS: Both the HA-based microneedle patch and EGF-containing HA-based microneedle patch had positive effects on WSRS score, patient satisfaction levels, and corneometer result with statistically significant differences. No significant side effects were noticed.
CONCLUSION: With respect to efficacy, no statistical difference between the two groups were noted, indicating that the anti-wrinkle effects of the microneedle patch may solely be due to the HA rather than the EGF.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jung U(신정우) ORCID logo https://orcid.org/0000-0001-5259-6879
Lee, Kwang Hoon(이광훈)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138401
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