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생분해성 마이크로니들 패치(Biodegradable Microneedle Patch)를 이용한 눈가 주름의 개선에 관한 연구
DC Field | Value | Language |
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dc.contributor.author | 신정우 | - |
dc.contributor.author | 이광훈 | - |
dc.date.accessioned | 2015-12-28T10:57:50Z | - |
dc.date.available | 2015-12-28T10:57:50Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0494-4739 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/138401 | - |
dc.description.abstract | BACKGROUND: Biodegradable microneedle technology is a recently developed method to deliver medical and pharmaceutical medications into the skin, and is expected to yield better treatment results than topical application methods. OBJECTIVE: To evaluate the efficacy of hyaluronic acid (HA)-based microneedle patches and epidermal growth factor (EGF)-containing microneedle patches on periorbital wrinkle improvement. METHODS: A 20-week randomized, double-blind study was performed. Twenty-five Korean patients with periorbital wrinkles and a wrinkle severity rating scale (WSRS) score above 2 were enrolled into the study. The patients completed the study using the two different types of patches on each side of the designated periorbital wrinkles area every other day for 8 weeks. Patients were requested for an additional 12-week follow up. Wrinkle improvements were assessed by WSRS score, subjective patient satisfaction score, and imaging analysis using the visiometer, corneometer, cutometer, and mexameter, respectively (Courage&Khazaka, Cologne, Germany). RESULTS: Both the HA-based microneedle patch and EGF-containing HA-based microneedle patch had positive effects on WSRS score, patient satisfaction levels, and corneometer result with statistically significant differences. No significant side effects were noticed. CONCLUSION: With respect to efficacy, no statistical difference between the two groups were noted, indicating that the anti-wrinkle effects of the microneedle patch may solely be due to the HA rather than the EGF. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 597~607 | - |
dc.relation.isPartOf | Korean Journal of Dermatology (대한피부과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 생분해성 마이크로니들 패치(Biodegradable Microneedle Patch)를 이용한 눈가 주름의 개선에 관한 연구 | - |
dc.title.alternative | Efficacy of Biodegradable Microneedle Patches on Periorbital Wrinkles | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학) | - |
dc.contributor.googleauthor | 박지훈 | - |
dc.contributor.googleauthor | 서지명 | - |
dc.contributor.googleauthor | 신정우 | - |
dc.contributor.googleauthor | 정도현 | - |
dc.contributor.googleauthor | 김정동 | - |
dc.contributor.googleauthor | 이광훈 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02149 | - |
dc.contributor.localId | A02674 | - |
dc.relation.journalcode | J02000 | - |
dc.subject.keyword | Epidermal growth factor | - |
dc.subject.keyword | Hyaluronic acid | - |
dc.subject.keyword | Microneedle patch | - |
dc.subject.keyword | Periorbital wrinkles | - |
dc.contributor.alternativeName | Shin, Jung U | - |
dc.contributor.alternativeName | Lee, Kwang Hoon | - |
dc.contributor.affiliatedAuthor | Shin, Jung U | - |
dc.contributor.affiliatedAuthor | Lee, Kwang Hoon | - |
dc.citation.volume | 52 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 597 | - |
dc.citation.endPage | 607 | - |
dc.identifier.bibliographicCitation | Korean Journal of Dermatology (대한피부과학회지), Vol.52(9) : 597-607, 2014 | - |
dc.identifier.rimsid | 49153 | - |
dc.type.rims | ART | - |
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