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생분해성 마이크로니들 패치(Biodegradable Microneedle Patch)를 이용한 눈가 주름의 개선에 관한 연구

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dc.contributor.author신정우-
dc.contributor.author이광훈-
dc.date.accessioned2015-12-28T10:57:50Z-
dc.date.available2015-12-28T10:57:50Z-
dc.date.issued2014-
dc.identifier.issn0494-4739-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/138401-
dc.description.abstractBACKGROUND: Biodegradable microneedle technology is a recently developed method to deliver medical and pharmaceutical medications into the skin, and is expected to yield better treatment results than topical application methods. OBJECTIVE: To evaluate the efficacy of hyaluronic acid (HA)-based microneedle patches and epidermal growth factor (EGF)-containing microneedle patches on periorbital wrinkle improvement. METHODS: A 20-week randomized, double-blind study was performed. Twenty-five Korean patients with periorbital wrinkles and a wrinkle severity rating scale (WSRS) score above 2 were enrolled into the study. The patients completed the study using the two different types of patches on each side of the designated periorbital wrinkles area every other day for 8 weeks. Patients were requested for an additional 12-week follow up. Wrinkle improvements were assessed by WSRS score, subjective patient satisfaction score, and imaging analysis using the visiometer, corneometer, cutometer, and mexameter, respectively (Courage&Khazaka, Cologne, Germany). RESULTS: Both the HA-based microneedle patch and EGF-containing HA-based microneedle patch had positive effects on WSRS score, patient satisfaction levels, and corneometer result with statistically significant differences. No significant side effects were noticed. CONCLUSION: With respect to efficacy, no statistical difference between the two groups were noted, indicating that the anti-wrinkle effects of the microneedle patch may solely be due to the HA rather than the EGF.-
dc.description.statementOfResponsibilityopen-
dc.format.extent597~607-
dc.relation.isPartOfKorean Journal of Dermatology (대한피부과학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title생분해성 마이크로니들 패치(Biodegradable Microneedle Patch)를 이용한 눈가 주름의 개선에 관한 연구-
dc.title.alternativeEfficacy of Biodegradable Microneedle Patches on Periorbital Wrinkles-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학)-
dc.contributor.googleauthor박지훈-
dc.contributor.googleauthor서지명-
dc.contributor.googleauthor신정우-
dc.contributor.googleauthor정도현-
dc.contributor.googleauthor김정동-
dc.contributor.googleauthor이광훈-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02149-
dc.contributor.localIdA02674-
dc.relation.journalcodeJ02000-
dc.subject.keywordEpidermal growth factor-
dc.subject.keywordHyaluronic acid-
dc.subject.keywordMicroneedle patch-
dc.subject.keywordPeriorbital wrinkles-
dc.contributor.alternativeNameShin, Jung U-
dc.contributor.alternativeNameLee, Kwang Hoon-
dc.contributor.affiliatedAuthorShin, Jung U-
dc.contributor.affiliatedAuthorLee, Kwang Hoon-
dc.citation.volume52-
dc.citation.number9-
dc.citation.startPage597-
dc.citation.endPage607-
dc.identifier.bibliographicCitationKorean Journal of Dermatology (대한피부과학회지), Vol.52(9) : 597-607, 2014-
dc.identifier.rimsid49153-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers

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