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Mouse Models of Gastric Carcinogenesis

Authors
 Sungsook Yu  ;  Mijeong Yang  ;  Ki Taek Nam 
Citation
 JOURNAL OF GASTRIC CANCER, Vol.14(2) : 67-86, 2014 
Journal Title
 JOURNAL OF GASTRIC CANCER 
ISSN
 2093-582X 
Issue Date
2014
Keywords
Helicobacter infections ; Mouse model ; Stomach neopla는
Abstract
Gastric cancer is one of the most common cancers in the world. Animal models have been used to elucidate the details of the molecular mechanisms of various cancers. However, most inbred strains of mice have resistance to gastric carcinogenesis. Helicobacter infection and carcinogen treatment have been used to establish mouse models that exhibit phenotypes similar to those of human gastric cancer. A large number of transgenic and knockout mouse models of gastric cancer have been developed using genetic engineering. A combination of carcinogens and gene manipulation has been applied to facilitate development of advanced gastric cancer; however, it is rare for mouse models of gastric cancer to show aggressive, metastatic phenotypes required for preclinical studies. Here, we review current mouse models of gastric carcinogenesis and provide our perspectives on future developments in this field.
Files in This Item:
T201404289.pdf Download
DOI
10.5230/jgc.2014.14.2.67.
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Nam, Ki Taek(남기택)
Yu, Sungsook(유성숙)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138313
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