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Multilayered implantation using acellular dermal matrix into nude mice.

DC FieldValueLanguage
dc.contributor.author노현-
dc.contributor.author이동원-
dc.contributor.author이명철-
dc.contributor.author이원재-
dc.date.accessioned2015-12-28T10:54:31Z-
dc.date.available2015-12-28T10:54:31Z-
dc.date.issued2014-
dc.identifier.issn0957-4530-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/138283-
dc.description.abstractSoft tissue augmentation using acellular dermal matrix has gained popularity to overcome the shortcomings of autogenous and alloplastic materials. Sometimes it needs multilayered stacking to obtain enough volume. In this study, we investigated the efficacy of multilayered implantation using acellular dermal matrix (MatriDerm(®)) for soft tissue augmentation. MatriDerm was implanted subdermally on each side of the dorsum of nude mice (n = 20), stacked two layers thick in the control group and three layers thick in the experimental group. Alterations of thickness, degree of angiogenesis, and collagen and elastin fiber syntheses were observed over 40 days. Three-layered implantation with MatriDerm maintained its volume similarly as in two-layered implantation, although the thickness decreased after 30 days in both groups. At the early stage of implantation, angiogenesis and collagen and elastin fiber syntheses occurred fluently on the central portion, which is the farthest away from the surface in contact with the host tissue. Collagen and elastin fibers became more concentrated over time, and the original structure of MatriDerm could not be maintained due to being replaced with newly formed collagen and elastin fibers 40 days after implantation. Multilayered implantation with MatriDerm is considered appropriate for tissue ingrowth and can be used as a substitute for soft tissue augmentation.-
dc.description.statementOfResponsibilityopen-
dc.format.extent2669~2676-
dc.relation.isPartOfJOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcellular Dermis*-
dc.subject.MESHAnimals-
dc.subject.MESHCollagen/metabolism*-
dc.subject.MESHCollagen/physiology-
dc.subject.MESHElastin/metabolism*-
dc.subject.MESHElastin/physiology-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHMice, Nude-
dc.subject.MESHNeovascularization, Physiologic/physiology*-
dc.subject.MESHSkin/cytology*-
dc.subject.MESHSkin/growth & development*-
dc.titleMultilayered implantation using acellular dermal matrix into nude mice.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Plastic Surgery & Reconstructive Surgery (성형외과학)-
dc.contributor.googleauthorDong Won Lee-
dc.contributor.googleauthorMyung Chul Lee-
dc.contributor.googleauthorHyun Roh-
dc.contributor.googleauthorWon Jai Lee-
dc.identifier.doi10.1007/s10856-014-5281-6-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02729-
dc.contributor.localIdA01301-
dc.contributor.localIdA02757-
dc.contributor.localIdA03005-
dc.relation.journalcodeJ01576-
dc.identifier.eissn1573-4838-
dc.identifier.pmid25056200-
dc.identifier.urlhttp://link.springer.com/article/10.1007/s10856-014-5281-6-
dc.subject.keywordMiddle Layer-
dc.subject.keywordAcellular Dermal Matrix-
dc.subject.keywordElastin Fiber-
dc.subject.keywordAcid Fuchsin-
dc.subject.keywordAlloplastic Material-
dc.contributor.alternativeNameRoh, Hyun-
dc.contributor.alternativeNameLee, Dong Won-
dc.contributor.alternativeNameLee, Myung Chul-
dc.contributor.alternativeNameLee, Won Jai-
dc.contributor.affiliatedAuthorLee, Dong Won-
dc.contributor.affiliatedAuthorRoh, Hyun-
dc.contributor.affiliatedAuthorLee, Myung Chul-
dc.contributor.affiliatedAuthorLee, Won Jai-
dc.rights.accessRightsfree-
dc.citation.volume25-
dc.citation.number12-
dc.citation.startPage2669-
dc.citation.endPage2676-
dc.identifier.bibliographicCitationJOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, Vol.25(12) : 2669-2676, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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