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Air atmospheric pressure plasma jet pretreatment for drop-wise loading of dexamethasone on hydroxyapatite scaffold for increase of osteoblast attachment.

Authors
 Jung Hwan Lee  ;  Jae Sung Kwon  ;  Yong Hee Kim  ;  Eun Ha Choi  ;  Kwang Mahn Kim  ;  Kyoung Nam Kim 
Citation
 JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, Vol.14(10) : 7654-7661, 2014 
Journal Title
 JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 
ISSN
 1533-4880 
Issue Date
2014
MeSH
3T3 Cells ; Air Pressure* ; Animals ; Cell Adhesion/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dexamethasone/chemistry* ; Dexamethasone/pharmacology* ; Drug Carriers/chemistry ; Drug Liberation ; Durapatite/chemistry* ; Mice ; Osteoblasts/cytology* ; Osteoblasts/drug effects ; Plasma Gases/chemistry* ; Tissue Scaffolds/chemistry*
Abstract
Periodontal disease affects alveolar bone resorption around the involved teeth. To gain bone height, bone graft materials have been widely used with drug carriers. Application of an atmospheric pressure plasma jet (APPJ) treatment is widely studied due to its ability to change surface characteristics without topographical change. The aim of this study is to identify whether the air APPJ (AAPPJ) treatment before drop-wise loading performance could change loaded amount of dexamethasone, and induce increase of cell attachment and proliferation. The results suggested that AAPPJ treatment decreased the contact angle down to about 13 degrees, which increased gradually but significantly lowered at least 4 days compared to no-treated group. After AAPPJ treatment, hydrocarbon was removed with change of zeta potential into positive charge. However, the AAPPJ treatment did not change the quantity or releasing profile of dexamethasone (p > 0.05). Confocal analysis combined with DNA proliferation analysis showed increase of osteoblast attachment and proliferation. Hence, AAPPJ could be a useful pretreatment method before drop-wise loading on HA scaffold with dexamethasone for increase of osteoblast attachment.
Full Text
http://www.ingentaconnect.com/content/asp/jnn/2014/00000014/00000010/art00049
DOI
10.1166/jnn.2014.9414
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Jae-Sung(권재성) ORCID logo https://orcid.org/0000-0001-9803-7730
Kim, Kyoung Nam(김경남)
Kim, Kwang Mahn(김광만) ORCID logo https://orcid.org/0000-0002-5235-0294
Lee, Jung Hwan(이정환)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138264
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