Cited 10 times in
Imidazolized magnetic nanovectors with endosome disrupting moieties for the intracellular delivery and imaging of siRNA
DC Field | Value | Language |
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dc.contributor.author | 서진석 | - |
dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2015-12-28T10:52:42Z | - |
dc.date.available | 2015-12-28T10:52:42Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 2050-750X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/138220 | - |
dc.description.abstract | The development of a synchronized delivery and imaging system for small interfering RNA (siRNA) is required for the clinical application of RNA interference (RNAi) in cancer treatment. Herein, we report a pH-responsive, magnetic nanoparticle-based siRNA delivery system that can facilitate the safe and efficient delivery and visualization of therapeutic siRNA by high-resolution magnetic resonance (MR) imaging. Cationic poly-L-lysine-graft-imidazole (PLI) with a reactive silane moiety was stably immobilized onto the surface of the assembled manganese ferrite nanoparticles (MFs) through an emulsion process, ensuring high water solubility, enhanced MR contrast effect, and endosome-disrupting functionality. The synthesized nanovectors were then complexed with siRNA targeting the CD44 gene via electrostatic interactions to verify the specific gene-silencing effect. The imidazolized magnetic nanovector (ImMNV) architectures developed here facilitated improved cellular internalization and exhibited a high level in vitro downregulation compared to non-imidazolized MNVs in metastatic breast cancer cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 8566~8575 | - |
dc.relation.isPartOf | JOURNAL OF MATERIALS CHEMISTRY B | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Imidazolized magnetic nanovectors with endosome disrupting moieties for the intracellular delivery and imaging of siRNA | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Eunjung Kim | - |
dc.contributor.googleauthor | Hwunjae Lee | - |
dc.contributor.googleauthor | Yonghee An | - |
dc.contributor.googleauthor | Eunji Jang | - |
dc.contributor.googleauthor | Eun Kyung Lim | - |
dc.contributor.googleauthor | Byunghoon Kang | - |
dc.contributor.googleauthor | Jin Suck Suh | - |
dc.contributor.googleauthor | Yong Min Huh | - |
dc.contributor.googleauthor | Seungjoo Haam | - |
dc.identifier.doi | 10.1039/C4TB01274G | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A04359 | - |
dc.relation.journalcode | J01573 | - |
dc.identifier.eissn | 2050-7518 | - |
dc.identifier.url | http://pubs.rsc.org/en/content/articlelanding/2014/tb/c4tb01274g#!divAbstract | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 2 | - |
dc.citation.number | 48 | - |
dc.citation.startPage | 8566 | - |
dc.citation.endPage | 8575 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MATERIALS CHEMISTRY B, Vol.2(48) : 8566-8575, 2014 | - |
dc.identifier.rimsid | 47231 | - |
dc.type.rims | ART | - |
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