카드뮴이 숫흰쥐의 불임에 미치는 영향에 관한 연구

Abstract

The morphological alteration in testies, epididymis, kidney, liver and the effect

on Lactic dehydrogenase activity in testis, kidney of rats were investigated after

administered 0.12㎎, 1.2㎎ of cadmium chloride per 100gm of body weight by a single

subcutaneous injection.

The results were as follows :

1. The testis of rats killed after candium administration were red dark. There

was profuse haemorrage into the interstitial tissues and other germinal elements in

the seminiferous tubules were undergoing degeneration.

2. The proximal end of the caput of epididymis revealed a haemorrage reaction.

The lining epithelium of the proximal caput was atrophied, the tubules were dilated

and spermatozoa with in the lumina were disintegrated.

3. Kindney and liver were not observedany morphologic alteration.

4. Total Lactic dehydrogenase activity of testis was higher than kidney in normal

group.

5. Experimental 1 injected 0.12㎎ of cadmium per 100gm of body weight, inhibited

LDH activity in testis tissue of rat. Inhibition rate of LDH activity of kidney was

higher than testis of rat.

6. Experimental 2 injected 1.2㎎ of cadmium per 100gm of body weight, also

inhibited LDH activity in testis of rat. Inhibition rate of LDH activity of kidney

was higher than testis of rat.