4. 톨루엔 노출농도와 혈청 GOT, GPT, rGT 및 혈청 STN 가수분해 효소 활성치 사이에는 통계학적으로 유의한 상관관계를 나타냈다.(p<0.01)
5. 혈청 STN 가수분해 효소 활성치에 영향을 미치는 요소중에서 톨루엔 노출농도가 가장 설명력이 높고, 통계학적으로 유의하였다.(p<0.05)
※ 핵심되는 말 : 유기용제, 간기능검사, 혈청 STN 가수분해 효소 활성
[영문]
To Measure the serum Succinyl trialanine p-nitroanilide hydrolytic activity as new index of liver function in workers exposed to organic solvents, this study conducted 114 workers in department of shoe-making of shoes factories.
The results obtained from this study were as follows :
1. The mean values of serum GOT, GPT rGT in whole workers were 22±12.32, 20±9.65, 28±21.35IU/l, respectively and the mean value of serum STN hydrolytic activity was 0.08±0.05.
2. The serum STN hydrolytic activity was significantly higher for male(p<0.05) and there was no difference among the groups of age.
3. There was no difference in the groups by working hours but significant difference in persons who worked over 3 years or were exposed to toluene over 100ppm (p<0.05).
4. The correlation of the exposed dose of toluene and serum STN hydrolytic activity were statistically significant (r=0.027-0.518).
5. The exposed dose of toluene was most explainable variable and statistically significant among the factors affecting serum STN hydrolytic activity(p<0.05).
※Key words : organic solvents, liver function text, serum STN hydrolytic activity