Correlation between abnormal pap smear finding and brachial-ankle pulse wave velocity in Korean women

Abstract

Cervical cancer is caused by chronic HPV infection. Pap smear is very efficient examination for early detecting cervical cancer. Inflammation reaction due to chronic infection is one of the major cause of atherosclerosis. Pulse wave velocity(PWV) is commonly used in predicting subclinical atherosclerosis. But no study was done about correlation between cervical cancer and PWV. The research population, 1779 people, had been chosen from the patients from Jan. 1st, 2008 to December 31st, 2010, visited health exam center who had done both PWV test and pap smear without any medical history of obstetrics and gynecological disease. The group was divided into to groups, 45 people with abnormal finding and 228 people with normal finding. And analyzed correlation between risk factor of cervical cancer and Brachial-Ankle PWV. Multiple regression analysis was done with associated variables. Average PWV of normal group was 1313.06±264.19 and abnormal was 1497.15±359.58, that PWV of abnormal group was higher. (p=0.0006) Analyzing association between risk factors of cervical cancer and PWV, age, height, weight, income, gravidity were associated. Multiple regression was done with correcting these variables. As a result, PWV was associated with abnormal pap smear result, but not statistically efficient (p=0.054) But more study is needed with correcting accurate date about HPV infection and smoking history for massive number of group.