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국민학교 아동에서 permethrin과 benzylbenzoate를 사용한 머릿니 집단 구제

Other Titles
 Therapeutic Effects of 24% Benzylbenzoate and 0.2% Permethrin on head louse infestation 
Authors
 배기수 
Issue Date
1990
Description
의학과/석사
Abstract

[영문] [한글] 최근 국내에 머릿니 감염이 국민학교 연령층 아동에게 높이 유행하는 것을 알고 이에 대한 구제책을 수립하고자, 경상북도 문경군 산북면을 선정하여 면내의 전체 국민학교 및 부설 유치원 아동을 대상으로 머릿니 감염율과 가정환경을 조사한 뒤 24% benzylbenzoat e 용액과 0.2% permethrin용액을 사용하여 집단약물치료를 시행하였으며, 3개월 경과 후 에 치료 효과를 조사하였다. 치료전 전체 아동 862 명 중 601 명(69.7%)이 감염되어 있었으며, 남자는 432명 중 232 명(53.77), 여자는 437명 증 309명(85.87)이 감염되어 여자의 감염율이 보다 높았다. 감염여부에 관계없이 전체 아동에게 24% benzylbenzoate 또는 0.2% permethrin 을 1주 간격으로 총 2회 살포한 뒤, 치료효과를 알아 보기 위한 치료 3개월 후 조사에서 862명 중 152명(17.6%)이 감염되어 있었으며 남아는 432명 중 35명(8.l%), 여아는 430명 증 117 명(27.2%)이 감염되어있어 치료전에 비하여 유의한 감염율의 저하를 보였다. 전체 7개 국민학고 862명 증 2개교 150명은 benzylbenzoate 로, 나머지 5개교 712명은 permethrin 으로 치료하였는데, 24% benzylbenzoate로 치료한 150명을 보면 감염자가 치 료전 115명(76.7%)에서 치료후 14명(9.3%)으로 감소되었으며, 0.2% permethrin 으로 치료 한 712 명은 감염자가 치료전 486 명(68.3%) 에서 치료후 83 명(18.9%)으로 감소되었다. 24% benaylbenzoate 치료군의 경우 0.2% permethrin 치료군에 비하여 감염율의 감소의 유 의한 차이를 볼 수 있었다 24% benzylbenzoate 용액이 0.2% permethrin 용액에 비하여 구제효과는 높았으나, 부작 용의 발현도가 대단히 높아 머릿니 구제용약제로 인체에 사용하기에는 커다란 제약이 따 름을 알 수 있었다. Therapeutic Effects of 24% Benzylbenzoate and 0.2% Permethrin on head louse infestation Ki Soo Pai Department Of Medica1 Science The Graduate School Yonsei University (Directed by Professor Jae Seung Lee, M. D. , PhD. ) Recently, there have been a few reports of high infestation rate of head louse in school aged children in Korea since 1984. Primary school and kindergarten children in Sanbuk-myon, Munkyong-gun, Kyungsangbuk-do were examined for head louse infestation rate and for demographic characteristics. Benzylbenzoate(24%) and permethrin(0.2%) were used in two treatment-groups separately to eradicate head louse and nit. All children, infested or not, were involved in the 7 day intervaled two therapeutic trials, and the result of treatment was evaluated 3 months later. Among 862 children, 601(69.7%) were infested. Among 432 male chiIdren, 232(53.7%) were infested while among 430 female children 369(85.8%) were infested, showing a significantly high infestation rate in female children(p<0.01), Three months after treatment, 152(17.6%) among 862 children were still infested with head louse and/or nit. Among them, 35 children(8.1%) were male and 117(27.2%) were female. There was a significant difference between the number of children infested before and after treatment (p<0.001) . Among the 150 children treated with 24% benzylbenzoate, 115 children(76.7%) were infested before treatment and 14(9.3%) after treatment. Among the 712 children treated with 0.2% permethrin,486(68.3%) were infested before treatment and 83(18.9%) were still infested after treatment, showing a significant difference in the treatment success rate between 24% benzylbenzoate and 0.2% permethrin. Among 232 male children and 369 female children infested before treatment, 35 male(15.l%) and 117 female(31.3%) had head louse and/or nit even after treatment, showing a higher treatmet failure rate in females(p<0.05) . Although 24% benzylbenzoate had a higher treatment success rate than 0.2% permethrin, the effacement of side effects were so high and severe making it difficult to choose benzylbenzoate as a suitable chemotherapeutic agent for eradication of head louse.
Full Text
https://ymlib.yonsei.ac.kr/catalog/search/book-detail/?cid=CAT000000045977
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1. College of Medicine (의과대학) > Others (기타) > 2. Thesis
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/135294
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