Gelfoam이 백서악골 손상치유에 미치는 영향에 관한 연구

Abstract

[영문]

[한글]

저자는 치과임상에서 발치와의 치유와 보철시술전 치조골 재생에 Gelfoam이 골손상 치

유 및 신생골 재생에 미치는 영향에 관하여 연구코저 백서 24마리를 이용하여 대조군과

실험군으로 구분하고 백서, 하악골 골체부에 손상을 낸후 실험군에는 Gelfoam편을 삽입하

여 실험후 1주, 2주, 3주, 4주후의 소견을 관찰한바 다음과 같은 유의한 결론을 얻었다.

1. 대조군은 염증세포 침윤이 1주만 현저 하였으며 2주 부터는 감소되는 경향을 보였다

.

2. 대조군에서 조골세포에 의한 새로운 골조직 형성은 2주부터 관찰 되었으며 4주에는

lamellation은 보이지 않지만 결손된 부위를 완전히 메우고 있었다.

3. Gelfoam을 사용한 실험군 에서는 염증세포 침윤이 2주까지 현저 하였으며 또한 괴사

된 골조직과 이물질에 의한 이물반응이 2주까지 관찰되었다.

4. Gelfoam을 사용한 실험군에서 새로운 골조직의 형성은 3주부터 관찰되기 시작하여 4

주에는 대조군과 유사한 소견을 보였다.

5. 골막골형성은 전군을 통하여 관찰되어 대조군과 실험군과의 차이를 볼수 없었다.

6. Gelfoam사용군은 대조군에 비하여 염증미 오래 지속되며 새로운 골조직의 형성도 지

연되는 경향을 보이나 4주부터는 대조군과 유사한 치유과정을 나타냈다.

A STUDY ON THE EFFECT OF GELFOAM PREPARATION ON THE HEALING OF EXPERIMENTAL BONE

DEFECT FO RATS.

Chang Joon Park

Dept. of Dental Science Graduate School, Yonsei University

(Directed by Professor JUNG HO YOON, D.D.S.,Ph.D.)

This study was undertaken to evaluate the effects of Gelfoam preparations on the

healing process of rat's mandibular bony defects.

24 rats, sprague dawley strain, weighing about 400gm were used, devided into

control group (4 rats) and experimental group (20 rats)

Six rats were sacrificed every one week serially for four weeks and prepared

microscopic slides with Hematoxylin-Eosin stain for pathological examination.

The obtained results from this study were as follows.

1. Acute and chronic inflammatory cell infiltration was remarkable in first week

control group and it showed decreasing tendency in second week control group.

2. New bone formation was found in second week control group and bony defect was

filled with osseous tissue devoiding of lamella structure.

3. Inflammatory cell infiltration was obvious up to second week experimental

group, foreign body reaction and necrotic bone were also observed.

4. New bone formation was noted in third week expeimental group and it showed

very similar findings with control group in fourth experimental group.

5. There was no definit distinction both in control and experimental group as to

periosteal bone formation.

6. There were persistant inflammatory reaction and delayed new bone formation in

experimental groups compared with control groups by fourth weeks.

Healing process was essentially the same in all groups.